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TDP-43 and Neurodegeneration: From Bench to Bedside de Vijay Kumar

TDP-43 and Neurodegeneration: From Bench to Bedside

Editat de Vijay Kumar, Manoj Kumar Jaiswal
en Limba Engleză Paperback – 26 oct 2021
Aggregates of the TAR DNA binding protein 43 (TDP-43), are hallmark features of the neurodegenerative diseases Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD), with overlapping clinical, genetic and pathological features.TDP-43 and Neurodegeneration: From Bench to Bedsidesummarizes new findings in TDP-43 pathobiology and proteinopathies. The book summarizes TDP-43’s structure, function, biology, misfolding, aggregation, pathogenesis and therapeutics. It includes autophagy-mediated therapy, role of stress granule, novel genetic, cell culture-based models, systems biology for precision medicine, development of stem cells and mechanism-based therapies that can target ALS and other related neurodegenerative diseases. This book is written for neuroscientists, neurologists, clinicians, advanced graduate students, drug discovery researchers, as well as cellular and molecular biologists involved in ALS, motor neuron disease (MND) and other neurodegenerative disorders.


  • Reviews TDP-43 structure, folding, function, and pathology
  • Identifies TDP-43 role in ALS, FTP, and other neurodegenerative diseases
  • Presents a systems and precision biology perspective of TDP-43
  • Discusses therapeutics of TDP-43 proteinopathies
  • Translates bench research to application bedside
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Specificații

ISBN-13: 9780128200667
ISBN-10: 0128200669
Pagini: 270
Dimensiuni: 152 x 229 x 18 mm
Editura: ELSEVIER SCIENCE

Cuprins

1. TDP-43: Past, Present and Future
2. Structural studies of TDP-43
3. TDP-43 mutations and Amyotrophic Lateral Sclerosis
4. Post translational modifications of TDP-43
5. TDP-43 and Autophagy
6. TDP-43 and Alzheimer Disease
7. TDP-43 and Stress granules
8. Repeat domains in TDP-43
8. Systems Biology of TDP-43
9. Animal models of TDP-43 in ALS
10. Therapeutic modulations of TDP-43

Descriere

Aggregates of the TAR DNA binding protein 43 (TDP-43), are hallmark features of the neurodegenerative diseases Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD), with overlapping clinical, genetic and pathological features. TDP-43 and Neurodegeneration: From Bench to Bedside summarizes new findings in TDP-43 pathobiology and proteinopathies. The book summarizes TDP-43’s structure, function, biology, misfolding, aggregation, pathogenesis and therapeutics. It includes autophagy-mediated therapy, role of stress granule, novel genetic, cell culture-based models, systems biology for precision medicine, development of stem cells and mechanism-based therapies that can target ALS and other related neurodegenerative diseases. This book is written for neuroscientists, neurologists, clinicians, advanced graduate students, drug discovery researchers, as well as cellular and molecular biologists involved in ALS, motor neuron disease (MND) and other neurodegenerative disorders.

 

  • Reviews TDP-43 structure, folding, function, and pathology
  • Identifies TDP-43 role in ALS, FTP, and other neurodegenerative diseases
  • Presents a systems and precision biology perspective of TDP-43
  • Discusses therapeutics of TDP-43 proteinopathies
  • Translates bench research to application bedside