This issue of Otolaryngologic Clinics, guest edited by Dr. Raj Sindwani, is devoted to Technological Advances in Sinus and Skull Base Surgery. Articles in this outstanding issue include: Evolution in Visualization for Sinus and Skull Base Surgery; Organism (Microbiome) Analysis Techniques and Implications for CRS; Topical drug therapies for CRS; Absorbable Biomaterials and Nasal Packing; Stents and Drug-Eluting Stents in Rhinology; Evolving Functionality and Applications of Microdebrider Technology; Innovation in Balloon Catheter Technology; Emerging Roles of Coblation in Rhinology and Skull Base Surgery; Application of Ultrasonic Aspirators in Rhinology and Skull Base Surgery; Next Tier Surgical Navigation Systems in Sinus and Skull Base Surgery; Robotics in Sinus and Skull Base Surgery; Emerging Role of 3-D Printing in Rhinology; Advances in Endoscopic Skull Base Reconstruction: An Evolution of Materials and Methods; and Integrated Full Solution Imaging and Intelligent Informatics.