F. M van Helmont’s Alphabet of Nature was one of many books published about language in the early modern period. The “language debate,” as it has come to be called, was a topic of compelling interest to major figures such as Reuchlin, Rabelais, Paracelsus, Agrippa, Postel, Boehme, Kircher, Hobbes, Descartes, Comenius, Spinoza, Locke, Boyle, Newton, and Leibniz. At issue were profound questions about whether language is natural or artificial, ordained by God or created by man. The answers given entailed a web of consequences that could lead to arrest, imprisonment, even execution. It is therefore not surprising that van Helmont wrote his book while imprisoned in the dungeons of the Roman Inquisition.