Corporations control everything. How you live. How many children you can have. What you do as an occupation.
George and Macy's father works for the corporations. When he discovers something the corporations want to remain hidden, they kill him and attempt to kill George. But Ma and Macy are gone when it happens.
George survives, but is changed. Knowing that the corporations will be back, Ma decides to move the family. Or what is left of it.
This is where their adventure begins as Macy and George begin to discover that they aren't ordinary children...and that Ma isn't an ordinary woman.