"In today's wars, there are no morals. We believe the worst thieves in the world today, and the worst terrorists, are the Americans. We do not have to differentiate between military or civilian. As far as we are concerned, they are all targets." -Osama bin Laden Sometime in the near future, a dying woman is discovered in New York City - infected with Smallpox. As the disease starts to spread, it is discovered that terrorists have unleashed a biological weapon on the American population - and brought the world to the brink of Armageddon. Against this backdrop, an extraordinary cast of men and women fight desperately for survival in a world gone mad. Doctor Nicolas Awad struggles desperately to contain and control the outbreak; President Paula Handley struggles to rally the shattered country for war and preserve something of the American way of life. On the streets of New York, Sergeant Al Hattlestad and the NYPD try to keep order and save as many as possible, while survivalist Jim Revells takes his family and tries to hide from the chaos. But the nightmare has only just begun...