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The Design and Development of Novel Drugs and Vaccines: Principles and Protocols

Editat de Tarun Kumar Bhatt, Surendra Nimesh
en Limba Engleză Paperback – 22 ian 2021
The Design and Development of Novel Drugs and Vaccines: Principles and Protocols presents both in silico methods and experimental protocols for vaccine and drug design and development, critically reviewing the most current research and emphasizing approaches and technologies that accelerate and lower the cost of product development. Sections review the technologies and approaches used to identify, characterize and establish a protein as a new drug and vaccine target, cover several molecular methods for in vitro studies of the desired target, and present various physiological parameters for in vivo studies. The book includes preclinical trials and research, along with information on FDA approval.

  • Covers both in silico methods and experimental protocols for vaccine and drug development in a single, accessible volume
  • Offers a holistic accounting of how developments in bioinformatics and large experimental datasets can be used in the development of vaccines and drugs
  • Shows researchers the entire gamut of current therapies, ranging from computational inputs to animal studies
  • Reviews the most current, cutting-edge research available on vaccine and drug design and development
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Specificații

ISBN-13: 9780128214718
ISBN-10: 0128214716
Pagini: 308
Ilustrații: 60 illustrations (30 in full color)
Dimensiuni: 152 x 229 x 22 mm
Greutate: 0.66 kg
Editura: ELSEVIER SCIENCE

Public țintă

Researchers and advanced students in life sciences, pharmacology, chemistry, biochemistry, toxicology and pharmaceutical science.

Cuprins

1. Introduction of structural bioinformatics with respect to drug discovery
2. Target identification and validation
3. Retrieval of compounds
4. Lead identification and optimization
5. Molecular dynamics simulations
6. An overview of vaccine design
7. Key steps in the selection of vaccine targets
8. Epitope prediction and selection of linkers and adjuvant
9. Design of vaccine constructs
10. In-silico validation through protein-protein docking
11. Molecular cloning
12. Protein expression
13. Protein purification and desalting
14. Biological assay
15. Biophysical methods
16. Outline of animal study for lead/ vaccine testing
17. Evaluation of immunogenicity of vaccine candidate
18. In-vitro evaluation of lead molecule
19. Medical physiological parameter for lead/vaccine testing
20. Brief introduction of clinical research and trials
21. An overview of IND, NDA, approval agencies and FDA post-marketing surveillance
22. Introduction of Intellectual property rights

Recenzii

"I have read other books on clinical research, but none with the level of detail and particular focus on drug design (the computational drug design sections) that this one has. This book is very detailed-oriented from that standpoint, and it can certainly serve as a useful tool for those developing vaccines." --© Doody’s Review Service, 2021, Patrick J Scoble, PharmD(PJS Pharma Consulting LLC), reviewer, expert opinion