To try to understand the person and philosophical work of Kwame Nkrumah is to engage in the exploration of a very complex historical phenomenon. Indeed, Nkrumah itself embodies the history of his own person, his family and his kingdom of origin, but also the contradictory history of Ghana and all of Africa, from colonization to the struggle for independence, from nominal independence to the neo-colonization of the entire world. continent whose population still languishes under the yoke of slavery by rich countries and their multinationals. Most readers of this great African philosopher and politician limit themselves to his political work and forget to read his scientific and philosophical writings, writings that form the theoretical foundation of his vision and political practice for the full independence of Africa. and your unit. This study briefly examines this important dimension of Nkrumah's work through his "epistemological revolution" initiated in his work in 1945.