The Great Anti-American Novel is a memoir written by a confessed mass-murderer in an offshore federal detention facility. The narrator's penetratingly satirical story centers on his small family coming together and being ripped apart by a global economic and cultural collapse that triggers a second American civil war, setting up the events that ultimately result in Dante Thompson and his adopted sister Sylvia orchestrating and carrying out an explosive, blood-gushingly violent retribution for the tragic and untimely deaths of their heroic father and former nation.