The girls are all back in this fast paced sequel to the Ladies of D-block. Prentiss, Lisa and Amanda are shipped off to the notorious David Blocker prison. They'll soon discovery there are only two types of people in prison, predators and prey. They'll have to become one or the other to keep from being eaten alive. Prentiss is still in a state of denial about the choices she's made. Even when confronted with the consequences of those choices. The sheltered suburban girl is going to get a fast lesson on prison life. Amanda is surprised by the reaction she receives by the Sisterhood when she arrives. She could seek safety within their numbers or shun their racist belief and try to survive on her own. Lisa accepts her situation and has to learn how to adapt to where she will spend the rest of her days. She picks up on a hustle that will keep her with the eceteras of prison life. Dre is days away from going home when she finds out there is a price on her head. She has to scramble to find the who and why to make it out alive. Newly minted corrections officer Chuck Stanton tries to adjust to his new job. He's quickly disillusioned by the disparity from training to practice. Plus, problems at home keep him busy as well. The ladies of D-block 2, starts now.