For years, Mighty-Girl has been a defender of truth, justice and the American way, but now that she's thirteen, she's starting to grow up and as her body changes so do her priorities. Now she, and her two sidekicks, Electra-Girl and Aqua-Girl not only have to fight bad-guys, this time in the form of Mafia Don Vito DiRusso, and his band of thugs, but their rapidly changing hormones and the fact that they're moving from being young girls to young women, and the latter is proving to be much more formidable than the former.