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The Orexin/Hypocretin System: Functional Roles and Therapeutic Potential

Editat de Jim R. Fadel, Joshua A. Burk
en Limba Engleză Paperback – 10 ian 2019
The Orexins/Hypocretins System: Functional Roles and Therapeutic Potential summarizes research on both the physiological functioning of orexins, their impact on homeostatic processes, and related disorders. The book encompasses the effects on appetite, sleep, substance abuse, cognition, and anxiety. Additionally, it examines new therapeutic approaches utilizing orexins, including utilization of orexin receptors for drug development. It is essential reading for neuroscience researchers interested in brain-behavior relationships, as well as psychiatrists, endocrinologists and pharmacologists.


  • Provides an overview of new research on orexins/hypocretins
  • Includes an overview of intracellular signaling and orexin physiology
  • Discusses the effects on arousal, appetite, cognition, addiction and anxiety
  • Examines orexin based therapies and their potential use in disorders
  • Explores orexin receptors for drug development
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Specificații

ISBN-13: 9780128137512
ISBN-10: 0128137517
Pagini: 188
Dimensiuni: 152 x 229 x 16 mm
Editura: ELSEVIER SCIENCE

Public țintă

Researchers, clinicians, postdoctoral fellows and graduate students in behavioral neuroscience, clinical neuroscience, neuroendocrinology, pharmacology, psychiatry, and psychology

Cuprins

Part 1: Introduction 1. Hypocretins (orexins): 20 years of dissecting arousal circuits 2. Orexins and motivated behaviors
Part 2: Orexins and Sleep 3. Orexins and the stabilization of wake/sleep states 4. Orexins and narcolepsy in animal models
Part 3: Orexins and Feeding 5. Orexin’s role in motivated behavior for food 6. Orexin drives energy expenditure
Part 4. Orexins and Drug Abuse 7. Orexins/hypocretins and addiction 8. Hypocretin 1 receptor regulation of dopaminergic signaling and motivated behavior 9. Orexins and opioid addiction
Part 5: Orexins and Cognition 10. Orexins and cognition: neurochemical and anatomical substrates 11. The hypocretin/orexin system and fear learning
Part 6: Orexins and Psychological Disorders 12. Orexins and anxiety disorders 13. Orexins as targets for treating brain disorders