Karen Hunter and her Major Crimes Unit of the Middlefield, Georgia Police Department are visited by a psychic in early March who tells them about two murders. Karen and her team are mystified because no murders have been reported, so they disbelieve the psychic and ESP in general. Later that month, a missing person report is filed for Dana McPhee, a prominent physicist and professor by his wife, Anne Kelly who is also an internationally known archaeologist and professor attending the annual Archaeology Conference at Middlefield College. McPhee had gone to the hotel lounge, but had not returned. Two days after the report was filed; Police find that both professors have been murdered. Anne Kelly was found strangled in her hotel room and Dana McPhee was found shot to death in an old, rundown house in Middlefield. Karen remembers that the psychic had said that a woman was with the man she had 'seen' murdered, but Karen and the MCU can make no sense of it. Eight ciphers are sent by an unknown person to Karen. She believes the ciphers contain critical clues to solving the murders. Curiously, GBI tells Karen that another man was shot to death in Macon on the same night as the professors. Karen and the MCU must solve the ciphers to find the killer.