The Pineal Gland and Cancer: Neuroimmunoendocrine Mechanisms in Malignancy

Section I: Significance of the Pineal Gland and Its Hormone Melatonin.- 1 Some Historical Remarks Concerning Research on the Pineal Gland and Cancer.- 2 Biology of the Pineal Gland and Melatonin in Humans.- 3 The Role of Melatonin in the Neuroendocrine System: Multiplicity of Sites and Mechanisms of Action.- 4 The Pineal Gland and Chronobiologic History: Mind and Spirit as Feedsidewards in Time Structures for Prehabilitation.- 5 Melatonin Involvement in Cancer: Methodological Considerations.- Section II: Effect of Tumor Growth on the Production and Secretion of Pineal Melatonin.- 6 Analysis of Melatonin in Patients with Cancer of the Reproductive System.- 7 Melatonin in Patients with Cancer of Extra-Reproductive Location.- 8 The Modulation of Melatonin in Tumor-Bearing Animals: Underlying Mechanisms and Possible Significance for Prognosis.- 9 The Pineal Gland, Melatonin, and Neoplastic Growth: Morphological Approach.- Section III: Effects of Melatonin and of Unidentified Pineal Products on Tumor Growth.- 10 In Vitro Effects of Melatonin on Tumor Cells.- 11 Melatonin and Colon Carcinogenesis.- 12 Role of Extrapineal Melatonin and Related APUD Series Peptides in Malignancy.- 13 A Survey of the Evidence That Melatonin and Unidentified Pineal Substances Affect Neoplastic Growth.- 14 Experimental Studies of the Pineal Gland Preparation Epithalamin.- Section IV: Mechanisms of Action of Melatonin on Tumor Cells.- A. Actions Via the Endocrine System.- 15 An Overview of the Neuroendocrine Regulation of Experimental Tumor Growth by Melatonin and Its Analogues and the Therapeutic Use of Melatonin in Oncology.- 16 Modulation of the Estrogen Response Pathway in Human Breast Cancer Cells by Melatonin.- 17 Benign and Tumor Prostate Cells as Melatonin Target Sites.- B. Actions Via theImmune System.- 18 Neuroimmunomodulation Via the Autonomic Nervous System.- 19 Melatonin and Immune Functions.- 20 Melatonin and the Immune System: Therapeutic Potential in Cancer, Viral Diseases, and Immunodeficiency States.- 21 Melatonin Rhythms in Mice: Role in Autoimmune and Lymphoproliferative Diseases.- 22 Mechanisms Involved in the Immunomodulatory Effects of Melatonin on the Human Immune System.- C Actions Via Neural Pathways.- 23 The Role of the Pineal Gland in Neural Control of Cell Proliferation in Healthy and Malignant Tissue.- D. Molecular Mechanisms of Action.- 24 Reactive Oxygen Species, DNA Damage, and Carcinogenesis: Intervention with Melatonin.- 25 Could the Antiproliferative Effect of Melatonin Be Exerted Via the Interaction of Melatonin with Calmodulin and Protein Kinase C?.- Section V: Oncotherapeutic Potential of Melatonin.- 26 Efficacy of Melatonin in the Immunotherapy of Cancer Using Interleukin-2.- 27 Melatonin Cancer Therapy.- Section VI: Electromagnetic Fields and Cancer: The Possible Role of Melatonin.- 28 Circadian Disruption and Breast Cancer.- 29 Breast Cancer and Use of Electric Power: Experimental Studies on the Melatonin Hypothesis.- 30 Magnetic Field Exposure and Pineal Melatonin Production (Mini-Review).- 31 Nocturnal Hormone Profiles in Healthy Humans Under the Influence of Pulsed High-Frequency Electromagnetic Fields.- 32 Weak High-Frequency (Radiofrequency, Microwave) Electromagnetic Fields: Epidemiological Evidence of Their Impact on Cancer Development and Reproductive Outcome.

First book to summarize the current state of research in pineal-cancer-interaction Includes supplementary material: sn.pub/extras