After a botched attempt to remove a curse from four innocent clients, Phyllis Ann Porre, the Great Voodoo Queen from New Orleans, is guilt-ridden and unable to forgive herself. For the first time in her forty-plus-year career, a case ended with the death of her clients. Phyllis Ann contemplates retirement from the paranormal and supernatural investigations. Unable to get past the guilt, Phyllis Ann hunkers down in her New Orleans cottage looking back over life until her granddaughter Mira Waugh visits from Memphis, forcing her back into venturing out. Tittle, Arkansas, a small town on the northeast side of the state, Buck Poston, along with his trusty friend Hawthorn Unger, decides to create an elixir of immortality in hopes of curing the stage four cancer growing in Buck's stomach. Using an old abandoned barn hidden on a secluded island toward the back of Peckerwood Lake in Prairie County, the desperate friends prepare for the sacrificial ceremony of a child. Targeting a child from Memphis, born into a special bloodline needed for the elixir, the friends move forward to carry out their plan. In one last investigation, Phyllis Ann, along with her understudy Kris Kinney from Memphis's Voodoo Village, use their spiritual gifts to assist the FBI during a desperate attempt to save the kidnaped child.