For many years, the protagonist and his uncle, Dr. Elihu Whipple, have nurtured a fascination with an old abandoned house on Benefit Street. Dr. Whipple has made extensive records tracking the mysterious, yet apparently, coincidental sickness and death of many who have lived in the house for over one hundred years. They are also puzzled by the strange weeds growing in the yard, as well as the unexplained foul smell, and whitish phosphorescent fungi growing in the cellar.After the protagonist discovers a strange, yellowish vapour in the basement, which seems to be coupled with a moldy outline of a huddled human form on the floor, he and his uncle decide to spend the night in the house, investigating the possibility of some supernatural force.