This synthesis provides information related to the Southern Nevada Agency Partnership (SNAP) Science and Research Strategy Goal 1 - to restore, sustain and enhance southern Nevada's eco-systems - and Goal 2 - to provide for responsible use of southern Nevada's lands in a manner that preserves heritage resources and promotes an understanding of human interaction with the land-scape. The Science and Research Strategy has nine Sub-goals that address the topics of water and water use, fire, invasive species, biological diversity, restoration, cultural resources, historic content, recreation, and science-based management. This synthesis summarizes the state-of-knowledge related to each of these Sub-goals, addresses knowledge gaps, and provides management impli-cations. It builds on previous efforts to develop the necessary scientific understanding for adaptive management of southern Nevada ecosystems.