The Vasculome: From Many, One
Editat de Zorina S. Galisen Limba Engleză Paperback – 14 iun 2022
Each section is preceded by an introductory summary that will give a high level unified view of the key concepts illustrated in the various chapters in that section.
Zorina Galis' The Vasculome was named a finalist in the Clinical Medicine category of the American Association of Publishers’ 2023 PROSE Awards.
- 2023 PROSE Awards - Winner: Finalist: Clinical Medicine: Association of American Publishers
- Brings together leading experts who present the latest biomedical thinking about the vasculature from the integrative perspective of the Vasculome
- Challenges traditional real and perceived boundaries within vascular research areas and stimulates new fundamental thinking and medical explorations
- Creates the bases for translating the integrative Vasculome concept into improved fundamental and clinical assessment and management of local and systemic contributions of the vasculature in health and disease
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Specificații
ISBN-13: 9780128225462
ISBN-10: 0128225467
Pagini: 526
Ilustrații: 200 illustrations (150 in full color)
Dimensiuni: 216 x 276 mm
Editura: ELSEVIER SCIENCE
ISBN-10: 0128225467
Pagini: 526
Ilustrații: 200 illustrations (150 in full color)
Dimensiuni: 216 x 276 mm
Editura: ELSEVIER SCIENCE
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Public țintă
basic and clinical researchers within various areas of Vascular Biology, Medicine and Cardiology; as well as researchers who need to understand the vasculome concept such as in fields of neuroscience, genetics, physiology, or pharmacologyCuprins
PART I. THE ARCHITECTURAL DESIGN OF THE VASCULOME: BASIS FOR SYSTEM-WIDE FUNCTIONAL UNITY AND LOCAL DIVERSITY
SECTION 1. The Endothelium: Key Unifying Principle of the Vasculome. Basis for Systemic Unity and for Engineering of Local Specialization
1. Developmental of, and environmental impact on, endothelial cell diversity
2. Endothelial cell heterogeneity in health and disease – new insights from single cell studies
SECTION 2. Vasculome’s Key Building Blocks - Beyond the Endothelium
3. The Remarkable Diversity of Vascular Smooth Muscle in Development and Disease: A paradigm for mesenchymal cell types
4. SMC contractile diversity
5. Resident vascular immune cells in health and atherosclerotic disease
6. Perivascular adipose tissue (physiology, pathology)
7. Major vascular ECM components, differential distribution supporting structure and functions of the Vasculome
SECTION 3. Putting it all Together: Integration across Body Scales and within Tissues
8. Out to the Tissues: The Arterial Side (Arteries, Arterioles - Development, Structure, Functions, Pathologies)
9. Capillary diversity: endothelial cell specializations to meet tissue metabolic needs
10. The neurovascular unit and blood-CNS barriers in health and disease
11. Lymphatic biology and medicine
PART II. INVESTIGATING THE VASCULOME: CONTEXT-DRIVEN METHODS, USES AND LIMITATIONS
SECTION 1. Experimental and Computational Studies of the Vasculome
12. The Flow-dependent Endotheliome: Hemodynamic Forces, Genetic Programs, and Functional Phenotypes
13. Intravital photoacoustic microscopy of microvascular function and oxygen metabolism’
14. Systems biology modeling of endothelial cell and macrophage signaling in angiogenesis in human diseases
15. Simulation of blood flow and oxygen transport in vascular networks
16. Clinical Investigations of vascular function
SECTION 2. Realizing the Promise of New High Content Technologies
17. Angiodiversity – A tale retold by comparative transcriptomics
18. Using Pattern Recognition and Discriminant Analysis of Functional Perfusion Data to Create “Angioprints for Normal and Perturbed Angiogenic Microvascular Networks
19. Artificial Intelligence (AI) for the Vasculome
PART III. VASCULOME DYNAMICS: IN HEALTH AND IN SICKNESS
SECTION 1. Cooperating during Development and Organogenesis to Create Vasculome Diversity
20. Vascular Development and Organogenesis: Depots of Diversity among Conduits of Connectivity Define the Vasculome
21. Normal Vascular Identity (arteries, veins, lymphatics) and malformations
22. Sprouting Angiogenesis in Vascular and Lymphatic development
SECTION 2. Physiological and Pathological Remodeling of the Vasculome
23. Enablers and drivers of vascular remodeling
24. Extracellular Matrix Dynamics and Contribution to Vascular Pathologies
25. Lymphatic vasculature anomalies and dysfunction
PART IV. THE VASCULOME AS PERPETRATOR AND VICTIM IN LOCAL AND SYSTEMIC DISEASES
26. Endothelial dysfunction: basis for many local and systemic conditions
27. The vascular phenotype in hypertension
28. Functional roles of lymphatics in health and disease
29. Extracellular Matrix Genetics of Thoracic and Abdominal Aortic Diseases
30. Peripheral arterial disease (pathophysiology, presentation, prevention/management)
31. Venous Diseases Including Thromboembolic Phenomena
PART V. THE VASCULOME IN DIAGNOSIS, PREVENTION, AND TREATMENT OF OTHER DISEASES
32. Targeting vascular zip codes: from combinatorial selection to drug prototypes
33. Angiosome concept for vascular interventions
34. RNA therapies for cardiovascular disease
35. The Brain Vasculome: An Integrative Model for CNS Function and Disease
PART VI. Looking Forward Toward "Precision Health" for the Vasculome
36. Defining and Optimizing Vascular health
37. The Vasculome provides a Body-wide Cellular Positioning System and Functional Barometer. The “Vasculature as Common Coordinate Frame (CCF) Concept
SECTION 1. The Endothelium: Key Unifying Principle of the Vasculome. Basis for Systemic Unity and for Engineering of Local Specialization
1. Developmental of, and environmental impact on, endothelial cell diversity
2. Endothelial cell heterogeneity in health and disease – new insights from single cell studies
SECTION 2. Vasculome’s Key Building Blocks - Beyond the Endothelium
3. The Remarkable Diversity of Vascular Smooth Muscle in Development and Disease: A paradigm for mesenchymal cell types
4. SMC contractile diversity
5. Resident vascular immune cells in health and atherosclerotic disease
6. Perivascular adipose tissue (physiology, pathology)
7. Major vascular ECM components, differential distribution supporting structure and functions of the Vasculome
SECTION 3. Putting it all Together: Integration across Body Scales and within Tissues
8. Out to the Tissues: The Arterial Side (Arteries, Arterioles - Development, Structure, Functions, Pathologies)
9. Capillary diversity: endothelial cell specializations to meet tissue metabolic needs
10. The neurovascular unit and blood-CNS barriers in health and disease
11. Lymphatic biology and medicine
PART II. INVESTIGATING THE VASCULOME: CONTEXT-DRIVEN METHODS, USES AND LIMITATIONS
SECTION 1. Experimental and Computational Studies of the Vasculome
12. The Flow-dependent Endotheliome: Hemodynamic Forces, Genetic Programs, and Functional Phenotypes
13. Intravital photoacoustic microscopy of microvascular function and oxygen metabolism’
14. Systems biology modeling of endothelial cell and macrophage signaling in angiogenesis in human diseases
15. Simulation of blood flow and oxygen transport in vascular networks
16. Clinical Investigations of vascular function
SECTION 2. Realizing the Promise of New High Content Technologies
17. Angiodiversity – A tale retold by comparative transcriptomics
18. Using Pattern Recognition and Discriminant Analysis of Functional Perfusion Data to Create “Angioprints for Normal and Perturbed Angiogenic Microvascular Networks
19. Artificial Intelligence (AI) for the Vasculome
PART III. VASCULOME DYNAMICS: IN HEALTH AND IN SICKNESS
SECTION 1. Cooperating during Development and Organogenesis to Create Vasculome Diversity
20. Vascular Development and Organogenesis: Depots of Diversity among Conduits of Connectivity Define the Vasculome
21. Normal Vascular Identity (arteries, veins, lymphatics) and malformations
22. Sprouting Angiogenesis in Vascular and Lymphatic development
SECTION 2. Physiological and Pathological Remodeling of the Vasculome
23. Enablers and drivers of vascular remodeling
24. Extracellular Matrix Dynamics and Contribution to Vascular Pathologies
25. Lymphatic vasculature anomalies and dysfunction
PART IV. THE VASCULOME AS PERPETRATOR AND VICTIM IN LOCAL AND SYSTEMIC DISEASES
26. Endothelial dysfunction: basis for many local and systemic conditions
27. The vascular phenotype in hypertension
28. Functional roles of lymphatics in health and disease
29. Extracellular Matrix Genetics of Thoracic and Abdominal Aortic Diseases
30. Peripheral arterial disease (pathophysiology, presentation, prevention/management)
31. Venous Diseases Including Thromboembolic Phenomena
PART V. THE VASCULOME IN DIAGNOSIS, PREVENTION, AND TREATMENT OF OTHER DISEASES
32. Targeting vascular zip codes: from combinatorial selection to drug prototypes
33. Angiosome concept for vascular interventions
34. RNA therapies for cardiovascular disease
35. The Brain Vasculome: An Integrative Model for CNS Function and Disease
PART VI. Looking Forward Toward "Precision Health" for the Vasculome
36. Defining and Optimizing Vascular health
37. The Vasculome provides a Body-wide Cellular Positioning System and Functional Barometer. The “Vasculature as Common Coordinate Frame (CCF) Concept
Recenzii
"...a holistic approach to understanding the human vascular system [which] highlights the importance of understanding human vasculature as a complex body-wide system, encouraging readers to think critically and holistically about its contributions to health and disease.... [I]ntended audience of this book includes clinical researchers and medical practitioners.... Within each section, there are many evidence-based figures and tables, which are adequately digestible with sufficient detail. [Has] an excellent [quality], and a valuable resource for medical practitioners in all specialties as well as researchers who are laying the groundwork for medical advancement." --©Doody’s Review Service, 2022, Sarah G Bridgeman, BA, MD Candidate (East Tennessee State University Quillen College of Medicine)