The Welshman's Wife tells the story of three generations of Welsh-Americans and the love they find and lose as they battle with their own inner demons. Lizzie, the beautiful daughter of a prominent salt maker in Charleston, West Virginia who falls in love with Layton Williams, survives the tragedy of the Civil War only to battle with her own inner demons. Her daughter Sarah, willful and beautiful but always haunted by grief and disappointment in those who love her. Charlie, her oldest son. Passionate and wild, cruel and lethal. When he meets Lilus, the daughter of a Texas farmer, she gives him one last chance at redemption, someone who loves him unconditionally and forgives his failings. They go to Colorado to find a new life but a tragedy exposes a darkness in Charlie that his family fears.