Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders
Editat de Lucia Morbidelli, Benjamin Bonavidaen Limba Engleză Hardback – 13 feb 2019
Edited and written by internationally renowned experts in the field of novel therapeutics for cancer, this book is a valuable source for cancer researchers, medical scientists, clinicians, clinical pharmacologists, and graduate students.
- Provides readers with a clear overview of the recent findings and references as well as summaries, significant molecular pathways, and conclusions
- Discusses new ideas proposed and makes suggestions for further investigations that will advance the field
- Presents introductory and summary information on the contributions of the field, all the findings of the studies discussed, and projects future goals for research
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Specificații
ISBN-13: 9780128165454
ISBN-10: 0128165456
Pagini: 372
Ilustrații: Illustrated
Dimensiuni: 191 x 235 mm
Editura: ELSEVIER SCIENCE
ISBN-10: 0128165456
Pagini: 372
Ilustrații: Illustrated
Dimensiuni: 191 x 235 mm
Editura: ELSEVIER SCIENCE
Public țintă
cancer researchers, medical scientists, clinicians, graduate studentsCuprins
I. Applications of Nitric Oxide in Cancer1. Nitric Oxide-Releasing Engineered Nanoparticles: Tools for Overcoming Drug Resistance in Chemotherapy2. Reversal of Multiple Cancer Oncogenic Pleiotropic Properties by NO-modulating Therapies3. Antitumor Effect of a Metal Nonoate Through Angiogenesis Impairment4. Therapeutic Implications of the Nitric Oxide Pathway in the Angiogenesis of Tumors and Inflammatory-Related Disorders5. Nitric oxide and cancer: To inhibit or to induce iNOS – That is the Question?6. Arginine Metabolism Regulates Nitric Oxide Production in Melanoma Tumor Microenvironment to Provide Survival Advantage to Tumor Cells7. Cancer and Beyond: Discovery and Development of NO-releasing Therapeutics8. Nitric Oxide Scavenging-Based Therapies for Targeting Colorectal Cancer9. Therapeutic Aspects of Protein Denitrosylation10. Nitric Oxide-Releasing Functional Nanomaterials for Anticancer Therapy
II. Applications of Nitric Oxide in Inflammatory-Related Disorders11. The Role of Nitric Oxide on Vascular Dysfunction During Aging and Alzheimer’s Disease12. Carbonic Anhydrase Inhibitor – NO Donor Hybrids and Their Pharmacologic Applications13. Understanding the Roles of Nitric Oxide During Sepsis, an Inflammatory Disorder14. Nanoporous Materials: New Generation of Nitric Oxide Donors
III. Abstracts (Presentations at Conference in Siena, October 4th-5th, 2018)A. Serum Nitric Oxide Metabolites and The Incidence of Metabolic Syndrome and Its Phenotypes: A Population-Based Prospective StudyB. Nitric Oxide (NO): A Multifaceted Target for Reversal of Cancer Cell Pleiotropic Properties by NO-modulating TherapiesC. Pharmacology of Hepatoselective Nitric Oxide - Donors in NAFLD in MiceD. New NO-Releasing Doxorubicins as Targeted Therapy Against Chemoresistance in Castration-resistant Prostate Cancer: In Vitro and In Vivo EvaluationsE. Anticancer Effect of a Novel H2S-Hybrid Molecule on Human Breast Adenocarcinoma (MFC-7) and Human Breast Epithelial (MCF-10A) Cell LinesF. Heme Oxygenase-1 In Duchenne Muscular Dystrophy: Interaction with Nitric Oxide Synthase Pathway in Satellite Cells DifferentiationG. In Vitro Assessment of NitDox Toxicity Towards VasculatureH. The Regulation of GSNOR Expression Discloses the Role of S-nitrosylation in Aging and DiseaseI. Effects of Long-term Nitrite Supplementation on Gene Expressions of GLUT2, GLUT4 and Glucokinase in Male Obese Type 2 Diabetic RatsJ. Nitric Oxide Re-Instates Doxorubicin Cytotoxic and Pro-Immunogenic Effects in Refractory Breast CancerK. Anti-Cancer Activities of Erucin a H2S-donor Isothiocyanate from Eruca Sativa Mill.: Is H2S the Real Player?L. Hydrogen Sulfide as a Signaling Molecule in The Cardiovascular System: Actions and Interactions with NOM. Nitric Oxide in Cancer Resistance to Cisplatin: Tumor Associated Macrophages as Key Players.N. Therapeutic Potential of Nitric Oxide Modulation in Ocular Diseases: A Focus on Novel NO-Releasing MoleculesO. Pro-Apoptotic Effects of S-Nitrosothiols O-Chloro and M-Chloro S-Nitroso-Aryl-Amides in Human Breast Cancer Cell LinesP. Light Guided Production of Nitric Oxide and Singlet Oxygen for the Multi-Modal Treatment of CancerQ. Potential for Chemoprevention with Nitric Oxide- and Hydrogen Sulfide-Releasing DrugsR. H2S Metabolism in Colon Cancer Cells Exposed to Hypoxia
II. Applications of Nitric Oxide in Inflammatory-Related Disorders11. The Role of Nitric Oxide on Vascular Dysfunction During Aging and Alzheimer’s Disease12. Carbonic Anhydrase Inhibitor – NO Donor Hybrids and Their Pharmacologic Applications13. Understanding the Roles of Nitric Oxide During Sepsis, an Inflammatory Disorder14. Nanoporous Materials: New Generation of Nitric Oxide Donors
III. Abstracts (Presentations at Conference in Siena, October 4th-5th, 2018)A. Serum Nitric Oxide Metabolites and The Incidence of Metabolic Syndrome and Its Phenotypes: A Population-Based Prospective StudyB. Nitric Oxide (NO): A Multifaceted Target for Reversal of Cancer Cell Pleiotropic Properties by NO-modulating TherapiesC. Pharmacology of Hepatoselective Nitric Oxide - Donors in NAFLD in MiceD. New NO-Releasing Doxorubicins as Targeted Therapy Against Chemoresistance in Castration-resistant Prostate Cancer: In Vitro and In Vivo EvaluationsE. Anticancer Effect of a Novel H2S-Hybrid Molecule on Human Breast Adenocarcinoma (MFC-7) and Human Breast Epithelial (MCF-10A) Cell LinesF. Heme Oxygenase-1 In Duchenne Muscular Dystrophy: Interaction with Nitric Oxide Synthase Pathway in Satellite Cells DifferentiationG. In Vitro Assessment of NitDox Toxicity Towards VasculatureH. The Regulation of GSNOR Expression Discloses the Role of S-nitrosylation in Aging and DiseaseI. Effects of Long-term Nitrite Supplementation on Gene Expressions of GLUT2, GLUT4 and Glucokinase in Male Obese Type 2 Diabetic RatsJ. Nitric Oxide Re-Instates Doxorubicin Cytotoxic and Pro-Immunogenic Effects in Refractory Breast CancerK. Anti-Cancer Activities of Erucin a H2S-donor Isothiocyanate from Eruca Sativa Mill.: Is H2S the Real Player?L. Hydrogen Sulfide as a Signaling Molecule in The Cardiovascular System: Actions and Interactions with NOM. Nitric Oxide in Cancer Resistance to Cisplatin: Tumor Associated Macrophages as Key Players.N. Therapeutic Potential of Nitric Oxide Modulation in Ocular Diseases: A Focus on Novel NO-Releasing MoleculesO. Pro-Apoptotic Effects of S-Nitrosothiols O-Chloro and M-Chloro S-Nitroso-Aryl-Amides in Human Breast Cancer Cell LinesP. Light Guided Production of Nitric Oxide and Singlet Oxygen for the Multi-Modal Treatment of CancerQ. Potential for Chemoprevention with Nitric Oxide- and Hydrogen Sulfide-Releasing DrugsR. H2S Metabolism in Colon Cancer Cells Exposed to Hypoxia