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Therapeutic Monoclonal Antibodies de James W. Larrick

Therapeutic Monoclonal Antibodies

Autor James W. Larrick, C. Borrebaeck
en Limba Engleză Paperback – 1990
A review of therapeutic antibodies which have commercial potential. It discusses PCR cloning of Igs, immortalization by gene transfer, scale up production, infectious diseases, viruses, bacteria, parisites, inflammation/immunology, blood grouping, cells, cytokines, tumours and MDR.
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Specificații

ISBN-13: 9781349118960
ISBN-10: 1349118966
Pagini: 369
Ilustrații: XIII, 369 p.
Dimensiuni: 152 x 229 x 22 mm
Greutate: 0.56 kg
Ediția:1st ed. 1990
Editura: Palgrave Macmillan UK
Colecția Palgrave Macmillan
Locul publicării:London, United Kingdom

Cuprins

The use of in vitro immunization, cloning of variable regions and scid mice for the production of human monoclonal antibodies; construction of recombinant therapeutic monoclonal antibodies; antibody-mediated cancer diagnosis and therapy; current status and future perspectives of chemoimmunoconjugates for the treatment of cancer; gangliosides as targets for monoclonal antibody therapy of cancer; mouse antibodies to carcinomas; therapeutic implication of monoclonal antibodies against multidrug resistant tumour cells; radioimmunotherapy with 90yttrium-anti-idiotype monoclonal antibody; immunoconjugates of a protein synthesis inhibiting drug; human monoclonal anti-idiotypic antibodies against a murine monoclonal antibody (Mab17-1A) as an anti-tumour vaccine; uses of human monoclonal antibodies to human cytomegalovirus and varicella-zoster virus; development of a human monoclonal antibody against cytomegalovirus with the aim of passive immunotherapy; characterization of human anti-cytomegalovirus monoclonal antibodies; immunoprotective capacities of human and murine monoclonal antibodies recognizing serotype specific and common determinants of gram-negative bacteria; pharmocokinetics of xomen TM-E5 in animals and humans; radomized placebo-controlled study of E5 monoclonal antiendotoxin antibody; human monoclonal antibodies against human red blood cells; CD7 monoclonal antibodies; large scale production of monoclonal antibodies; European regulatory issues.