Tissue-Specific Toxicity: Biochemical Mechanisms

Editat de Wolfgang Dekant, H. G. Neumann

en Limba Engleză Hardback – 5 mar 1992

This volume provides an up-to-date review of the molecular mechanisms of toxicity. Individual chapters deal with specific aspects of toxicity problems associated with selected organs.

Contains a review of contemporary knowledge of the molecular mechanisms of toxicity as applied to various organs
Contrasts with other volumes in dealing with the mechanistic approach to the subject
Discusses selected organs in separate chapters

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Specificații

ISBN-13: 9780122088605
ISBN-10: 0122088603
Pagini: 263
Dimensiuni: 152 x 229 x 16 mm
Greutate: 0.56 kg
Editura: ELSEVIER SCIENCE

Public țintă

Research toxicologists, pharmacologists, oncologists, and physiologists.

Cuprins

D.J. McConkey, T.Y. Aw, and S. Orrenius, Role of the Ca2+-Mediated Endonuclease Activation in Chemical Toxicity. W.N. Aldridge, Selective Neurotoxicity: Problems in Establishing the Relevance of in Vitro data to the in Vivo Situation. J.E. Casida and R.F. Toia, Organophosphorous Pesticides: Their Target Diversities and Bioactivation. U. Andrae and H. Greim, Initiation and Promotion in Thyroid Carcinogenesis. W. Bursch, L. Fesus, and R. Schulte-Hermann, Apoptosis ('Programmed' Cell Death) and its Relevance in Liver Injury and Carcinogenesis. P. Steinberg and F. Oesch, Liver Cell Specific Toxicity of Xenobiotics. H.-G. Neumann, S. Ambs, and W. Hillesheim, The Biochemical Basis of Hepatotoxicity. W. DeKant, S. Vamvakas, and M.W. Anders, The Kidney as a Target Organ for Xenobiotics Bioactivated by Glutathione Conjugation. G.S. Yost, Bioactivation and Selectivity of Pneumotoxic Chemicals. M.E. Scheulen and H. Kappus, Anthracycines as Model Compounds for Cardiac Toxicity. Index.

Recenzii

"It is a fitting tribute to a man who spent much of his research career establishing the role of chemical specificity in toxicity." --ATLA

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