V knige predstavlena kharakteristika klinicheskikh i patogeneticheskikh osobennostey razlichnykh fenotipov tyazheloy bronkhial'noy astmy i khronicheskoy obstruktivnoy bolezni legkikh, dany patomorfologicheskie kriterii, otlichayushchie tyazheluyu bronkhial'nuyu astmu fenotipa astma fiksirovannoy bronkhial'noy obstruktsii i tyazheluyu stadiyu khronicheskoy obstruktivnoy bolezni legkikh. Dannaya rabota baziruetsya na kliniko-funktsional'nykh nablyudeniyakh, vypolnennykh v ramkakh mnogotsentrovykh randomizirovannykh issledovaniy i fundamental'nykh rabotakh po otsenke tkanevykh, kletochnykh i molekulyarnykh markerov remodelirovaniya bronkhov pri issleduemykh nozologiyakh. Monografiya prednaznachena dlya spetsialistov-morfologov, patologoanatomov, pul'monologov, immunologov, allergologov, terapevtov, a takzhe studentov i sotrudnikov meditsinskikh vuzov.