Toxicology of the Gastrointestinal Tract, Second Edition: Target Organ Toxicology Series
Editat de Shayne Cox Gaden Limba Engleză Hardback – 30 oct 2018
Appearing in this volume are also considerations of the microbiome and its actions and influence on the function of the GI tract and on the toxicity and pharmacodynamics of ingested substances (including nutrients, toxins, and therapeutics). These fifteen chapters written by experienced experts in the field address methods to evaluate GI function; specifics of GI function and toxicity assessment in canines and minipigs; classes of compounds with their toxicity; species differences; and the toxicity (and promise) of nanoparticles. Those needing to understand the structure, function, and methods of studying the GI tract will find this volume a singular source of reference.
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Specificații
ISBN-13: 9781138360167
ISBN-10: 1138360163
Pagini: 476
Ilustrații: 36
Dimensiuni: 156 x 234 x 33 mm
Greutate: 0.79 kg
Ediția:2
Editura: CRC Press
Colecția CRC Press
Seria Target Organ Toxicology Series
ISBN-10: 1138360163
Pagini: 476
Ilustrații: 36
Dimensiuni: 156 x 234 x 33 mm
Greutate: 0.79 kg
Ediția:2
Editura: CRC Press
Colecția CRC Press
Seria Target Organ Toxicology Series
Public țintă
Professional and Professional ReferenceCuprins
Preface
Editor
Contributors
Chapter 1 Introduction: The Gastrointestinal (GI) Tract as a Barrier and as an Absorptive and Metabolic Organ
Shayne C. Gad
Chapter 2 Methods for the Analysis of Gastrointestinal Function
Robin C. Guy
Chapter 3 Safety Pharmacology and the GI Tract
Henry I. Jacoby
Chapter 4 Gastrointestinal Tract Development and Its Importance in Toxicology
Alma M. Feldpausch, Joseph V. Rodricks, Rosalind A. Schoof and Brittany A. Weldon
Chapter 5 Gastrointestinal Tract as a Major Route of Pharmaceutical Administration
Robert W. Kapp, Jr.
Chapter 6 Gastrointestinal Function and Toxicology in Canines
Charles B. Spainhour
Chapter 7 Gastrointestinal Function and Toxicology in Minipigs
Maria R. Jones and Alain Stricker-Krongrad
Chapter 8 Absorption of Macromolecules by Mammalian Intestinal Epithelium
Shayne C. Gad
Chapter 9 Peyer’s Patch Epithelium: An Imperfect Barrier and Effect of the Microbiome
Gary R. Burleson and Florence G. Burleson
Chapter 10 Alteration of Intestinal Function by Xenobiotic Exposure: Animal Models
Shayne C. Gad
Chapter 11 The Role of the Microbiome on Metabolism, Absorption, and Toxicity of Xenobiotics in the Gastrointestinal Tract
Shayne C. Gad
Chapter 12 Normal and Abnormal Intestinal Absorption by Humans
David W. Hobson and Valerie L. Hobson Balldin
Chapter 13 Classes of Compounds with GI Tract Toxicity
Amy L. Mihalchik and Erica N. Rogers
Chapter 14 Species Differences in GI Toxicity
Shayne C. Gad
Chapter 15 Nanoparticles in the Gastrointestinal Tract
David W. Hobson and Valerie L. Hobson Balldin
Index
Editor
Contributors
Chapter 1 Introduction: The Gastrointestinal (GI) Tract as a Barrier and as an Absorptive and Metabolic Organ
Shayne C. Gad
Chapter 2 Methods for the Analysis of Gastrointestinal Function
Robin C. Guy
Chapter 3 Safety Pharmacology and the GI Tract
Henry I. Jacoby
Chapter 4 Gastrointestinal Tract Development and Its Importance in Toxicology
Alma M. Feldpausch, Joseph V. Rodricks, Rosalind A. Schoof and Brittany A. Weldon
Chapter 5 Gastrointestinal Tract as a Major Route of Pharmaceutical Administration
Robert W. Kapp, Jr.
Chapter 6 Gastrointestinal Function and Toxicology in Canines
Charles B. Spainhour
Chapter 7 Gastrointestinal Function and Toxicology in Minipigs
Maria R. Jones and Alain Stricker-Krongrad
Chapter 8 Absorption of Macromolecules by Mammalian Intestinal Epithelium
Shayne C. Gad
Chapter 9 Peyer’s Patch Epithelium: An Imperfect Barrier and Effect of the Microbiome
Gary R. Burleson and Florence G. Burleson
Chapter 10 Alteration of Intestinal Function by Xenobiotic Exposure: Animal Models
Shayne C. Gad
Chapter 11 The Role of the Microbiome on Metabolism, Absorption, and Toxicity of Xenobiotics in the Gastrointestinal Tract
Shayne C. Gad
Chapter 12 Normal and Abnormal Intestinal Absorption by Humans
David W. Hobson and Valerie L. Hobson Balldin
Chapter 13 Classes of Compounds with GI Tract Toxicity
Amy L. Mihalchik and Erica N. Rogers
Chapter 14 Species Differences in GI Toxicity
Shayne C. Gad
Chapter 15 Nanoparticles in the Gastrointestinal Tract
David W. Hobson and Valerie L. Hobson Balldin
Index
Notă biografică
Shayne C. Gad, B.S. (Whittier College, Chemistry and Biology, 1971) and Ph.D. in Pharmacology/Toxicology (Texas, 1977), DABT, is the principal of Gad Consulting Services, a twenty-seven-year-old consulting firm with nine employees and more than 500 clients (including 140 pharmaceutical companies in the US and 50 overseas in 29 countries). Prior to this, he served in director-level and above positions at Searle, Synergen and Beckton Dickinson. He has published 50 books and more than 350 chapters, articles, and abstracts in the fields of toxicology, statistics, pharmacology, drug development and safety assessment. He has more than 42 years of broad-based experience in regulatory toxicology, drug and device development, statistics and risk assessment, and has specific expertise in neurotoxicology, in vitro methods, cardiovascular toxicology, inhalation toxicology, immunotoxicology, risk assessment, and genotoxicology. He is a past president of the American College of Toxicology, the Roundtable of Toxicology Consultants and three of SOT’s specialty sections. He has direct involvement in the preparation of INDs (118 successfully to date), NDA, PLA, ANDA, 501(k), IDE, CTD, clinical data bases for phase 1 and 2 studies, and PMAs, and served as the COO of two pharmaceutical companies while a consultant. He has consulted for FDA, EPA, and NIH, has trained reviewers and been an expert witness for FDA. He has also conducted the triennial toxicology salary survey as a service to the profession for the last 29 years. Dr. Gad is also a retired Navy officer with more than 26 years in service.
Descriere
The Second Edition of Toxicology of the Gastrointestinal Tract continues its mission to provide a complete and multidisciplinary overview of the gastrointestinal system both in health and as it is involved in the toxicity of exogenous agents. It features five new chapters, including one on species differences in G.I. toxicity.