Nearly everyone has been suffering from liver disorder and disease by higher intake of various medicines, beverages, alcohol, junk food and accidentally inhalation of chemicals, toxins etc. The liver plays a key role in metabolism and clearance of food and drugs which are susceptible to toxicity. Certain medicines, when taken in overdoses and sometimes introduced within therapeutic ranges, may lead to liver toxicity. More than 900 drugs and toxins have been reported to cause liver injury and several herbal remedies are administered to cure liver from these toxicity. Various drugs from plant sources traditionally used to protect liver and given in jaundice in many tribes all over the world. In India, People of Himalayan region traditionally use aerial parts of Roylea elegans (titpati) for protect their liver and crushed leaves are given to infants against jaundice.