This edited book uses a methodology that includes multidisciplinary collaboration to approach climate issues from several disciplines involved in climate governance. The main aim is to showcase collaborative research designed from the point of view of experiences associated with Indigenous Knowledge from an assumption of the equitable importance of its practices, methods of search, and cultural background that Indigenous Peoples custodians have maintained through time immemorial. In showing their applied ethics and activism to protect their traditional land, this book’s mission is to advocate the concept of climate justice absent from our mainstream academic and legal discourse. Their investigation into some real-life examples and local practices organised by Nature as their main element offers, inter alia, a detailed account of Indigenous Knowledge’s duty of care towards local biodiversity that can potentially be adopted in policy formulation on environmental management and governance. These selected essays represent an international human rights approach, a human understanding of genetic resources that existed for centuries alongside the First Nations and their strategies to mitigate the contemporary climate crisis afflicting all of us. The book revolves around Indigenous Knowledge of First Peoples, tribal and local communities in the Global South. In climate justice, Indigenous Peoples’ advocacy to protect our local biodiversity must be crucial change mitigation.