The National Institutes of Health Publication 05-5052 the Trainer's Guide for Cancer Education offers practical suggestions for trainers to enliven training programs, encourage more active participation, and enrich the learning experience for everyone involved in a clinical trial program or education series. The guide is divided into four sections: Adult Learning Principles, Plan, Implement, and Summary and Conclusion. The Adult Learning Principles underscores the importance of using the adult learning cycle to help participants apply skills learned beyond the training and assesses participants' strengths and needs to design an appropriate training. The Plan aids in defining an appropriate plan, training goals, and objectives, selecting appropriate training methods, principles for selecting and using audiovisual materials, and tips for developing a realistic, responsive training plan. The Implementation section provides ways to create a safe and comfortable learning environment, tips on facilitating the training, ideas on how to provide closure, and evaluations methods. Finally, the Summary and Conclusion puts it all together.