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Transcriptomics in Atherosclerosis: Deciphering Molecular Signatures and Advancing Therapeutic Strategies

Editat de Yvan Devaux, Miron Sopic
en Limba Engleză Paperback – sep 2025
Transcriptomics in Atherosclerosis: Deciphering Molecular Signatures and Advancing Therapeutic Strategies integrates transcriptomic research and RNA-based therapeutics to understand and treat atherosclerosis, emphasizing the power of genetic insights to revolutionize cardiovascular medicine. This book fills an essential gap by offering up-to-date insights into molecular mechanisms, diagnostic innovations, and therapeutic strategies, fostering a new era of personalized cardiovascular care. Specifically, readers will find information on cutting-edge RNA sequencing methods, clinical translation and multi-omics integration; as well as phenotyping and treatment stratification, complemented by a multi-omics approach to provide a holistic view of vascular pathology. “Transcriptomics in Atherosclerosis: Deciphering Molecular Signatures and Advancing Therapeutic Strategies” provides a deep understanding of disease mechanisms and potential interventions. Of great interest to readers will be the focus on RNA-based biomarkers and therapeutics for early detection, monitoring, and targeted interventions in atherosclerosis. Additionally, advanced transcriptomic technologies and their applications presents an illuminating exploration of novel RNA sequencing methods, including single-cell and spatial transcriptomics, and how they unveil the complexities of atherosclerotic disease. This book will doubtlessly be the one reached for by medical professionals seeking edification in this bourgeoning field.

  • Unravels the molecular intricacies of atherosclerosis using the latest transcriptomic technologies, offering new perspectives on disease mechanisms and potential therapeutic targets
  • Highlights the transformative potential of RNA molecules in advancing diagnostics and developing novel RNA-based treatments for personalized medicine in cardiovascular care
  • Provides actionable insights into translating transcriptomic findings into clinical applications, enhancing patient stratification, and treatment strategies
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Specificații

ISBN-13: 9780443330643
ISBN-10: 0443330646
Pagini: 300
Dimensiuni: 191 x 235 mm
Editura: ELSEVIER SCIENCE

Cuprins

Section I – Introduction
1. Atherosclerotic CVD – epidemiology and current challenges in management
2. Atherosclerotic Plaque Phenotypes: Unraveling Complexity and Heterogeneity

Section II – The role of RNAs in atherosclerosis progression and development
3. Biogenesis and mechanisms of action of ncRNAs
4. The role of ncRNA in plaque development and progression
5. Signaling Pathways Regulating Gene Expression in Atherosclerosis
6. Epitranscriptomics and Atherosclerosis:

Section III – Transcriptomic Profiling of Atherosclerotic Lesions
7. Essentials of Transcriptomic Methods: Navigating Through RNA Sequencing and Beyond
8. Bridging the Gap in Transcriptomics: From Animal to Human Studies in Atherosclerosis
9. Translating Transcriptomics into Clinical Practice: Utilizing Gene Expression Patterns for Advanced Patient Phenotyping and Stratification in Atherosclerosis Optimizing Study Design for In-depth Transcriptomic Analysis of Atherosclerotic Plaques
10. Unveiling Sex-Specific Transcriptomic Mechanisms in Atherosclerosis

Section IV – Integrating Multi-Omics Approaches in Atherosclerosis Research
11. Combining Transcriptomics with Genomics, Proteomics, and Metabolomics
12. Insights into Gene Regulatory Networks in Vascular Pathology
13. Systems Biology and Network Analysis
14. Use of artificial intelligence and machine learning for multi-omics

Section V – RNA-Based Theranostics: Revolutionizing Treatment and Diagnosis in Atherosclerotic Cardiovascular Disease
15. RNA Therapeutics in Atherosclerosis:
16. RNA Therapeutic Delivery Systems – advances and challenges
17. Exploring Circulating RNAs: Emerging Biomarkers for Atherosclerosis Detection and Monitoring

Section VI – Conclusion
18. Future Directions and Emerging Technologies in Transcriptomic Research and Atherosclerosis