This book reviews the past 30 years of space-based research across the Atlantic. The focus of the book is 13 U.S.-Europe missions in astrophysics, space physics, planetary sciences, earth sciences, and life and microgravity research that illustrate 'lessons learned" on the evolution of cooperation, mission planning and scheduling, international agreements, cost sharing, management, and scientific output. These lessons form the basis of the committees' findings and recommendations for improving future conduct and enhancing scientific output from cooperation and collaboration between the United States and Europe.