This is book is clinical guide intended for those suffering depression as well as family members acting as care givers. It's a comprehensive look into the causes, treatments options, medication and family response. It will help the reader cope better with this insidious and pernicious mental disorder. Depression affecting millions of persons globally. An estimated 14 million affected in the U.S. Depression is a physical mental condition interfering with everyday life. It's condition caused changes in neuro-transmitters in the brain take place; and mental because changes in neuro-transmitters that may lead to changes in mental mood and behavior without apparent reasons. A neuro-transmitter is defined as 'chemical' substance produced within the brain for the purpose of establishing normal communication between neurons, the cells that regulate mental activity in the brain. At a simplified explanation, chemical substances ferrying information from neuron to neuron (cells within the brain) become unable of such function for unknown reasons. Clinical depression is an insidious and pernicious mental disorder - mental condition - affecting millions of persons globally and in the U.S. Depression is a physical mental condition interfering with everyday life. Physical because it occurs as changes in neuro-transmitters in the brain take place; and mental because changes in neuro-transmitters may lead to changes in mental mood and behavior without apparent reasons. A neuro-transmitter is defined as 'chemical' substance produced within the brain for the purpose of establishing normal communication between neurons, the cells that regulate mental activity in the brain. At a simplified explanation, chemical substances ferrying information from neuron to neuron (cells within the brain) become unable of such function for unknown reasons. Clinical depression is an insidious and pernicious mental disorder - mental condition - affecting millions of persons globally and in the U.S. Depression is a physical mental condition interfering with everyday life. Physical because it occurs as changes in neuro-transmitters in the brain take place; and mental because changes in neuro-transmitters may lead to changes in mental mood and behavior without apparent reasons. A neuro-transmitter is defined as 'chemical' substance produced within the brain for the purpose of establishing normal communication between neurons, the cells that regulate mental activity in the brain. At a simplified explanation, chemical substances ferrying information from neuron to neuron (cells within the brain) become unable of such function for unknown reasons.