Based on actual events, "White Buffalo" tells the story of the miracle birth of a white buffalo calf on a small farm in southern Wisconsin. When Carol Gelling discovers that one of the buffalo on her farm is born white in color, she thinks nothing more of it than a curiosity. Soon, however, she learns that this is the fulfillment of an ancient prophecy believed by the Sioux to bring peace on earth and unity to all mankind. Her little farm is quickly overwhelmed with religious pilgrims, bringing her into contact with a culture and faith that is wholly unfamiliar to her. When a mysterious businessman offers to buy the calf for two million dollars, Carol is thrown into doubt about whether to profit from the religious beliefs of others or to keep true to a spirituality she knows nothing about.