The winners in business have shifted markedly in the last decade. When the 2010s began, the world's ten most valuable public companies by market capitalization were based in five countries, only two of them were in the tech sector, and none was worth more than $400 billion. Today, all of the top ten are in the US and China, the majority are tech companies, and some at least temporarily have surpassed $1 trillion in value. Given the relentlessness of change on multiple dimensions, the keys to success are likely to be just as different in ten years' time. What will it take to win in the 2020s?