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Acute Neuronal Injury: The Role of Excitotoxic Programmed Cell Death Mechanisms de Denson G. Fujikawa

Acute Neuronal Injury: The Role of Excitotoxic Programmed Cell Death Mechanisms

Editat de Denson G. Fujikawa
en Limba Engleză Paperback – 14 dec 2018
An overview of the biochemical mechanisms that produce acute nerve cell death in the brain. Covers injuries and disorders including stroke, brain and spinal cord trauma, hypoglycemic coma, and prolonged epileptic seizures. All of these lead to high concentrations of calcium in nerve cells which, in turn, causes degradation of cytoplasmic proteins, cleavage of nuclear DNA, and eventually cell death. 

The Second Edition contains 11 thoroughly updated chapters and 3 additional chapters that did not appear in the previous edition.
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Specificații

ISBN-13: 9783030084684
ISBN-10: 303008468X
Pagini: 215
Ilustrații: XII, 215 p. 39 illus., 24 illus. in color.
Dimensiuni: 155 x 235 mm
Ediția:Softcover reprint of the original 2nd ed. 2018
Editura: Springer International Publishing
Colecția Springer
Locul publicării:Cham, Switzerland

Cuprins

Introduction.- Excitotoxic programmed cell death involves caspase-independent mechanisms.- To survive or to die: how neurons deal with it.- Oxidative damage mechanisms in traumatic brain injury and antioxidant neuroprotective approaches.- Mitochondrial damage in traumatic CNS injury.- Neuroprotective agents target molecular mechanisms of programmed cell death after traumatic brain injury.- Involvement of apoptosis-inducing factor (AIF) in neuronal death following cerebral ischemia.- Apoptosis-inducing factor translocation to nuclei after transient global ischemia.- Necroptosis in cerebral ischemia.- Histological and elemental changes in ischemic stroke.- Hypoglycemic brain damage.- Activation of caspase-independent programmed pathways in seizure-induced neuronal necrosis.- Conclusion.

Notă biografică

Dr. Denson Fujikawa is an Adjunct Professor of Neurology at the David Geffen School of Medicine at UCLA, a member of the Brain Research Institute at UCLA and a Staff Neurologist at the Department of Veterans Affairs Greater Los Angeles Healthcare System. His interest in mechanisms of nerve cell death in the brain began during a two-year epilepsy research fellowship with Dr. Claude Wasterlain, from 1981 to 1983. He is a Fellow of the American Academy of Neurology and is a member of the American Epilepsy Society, American Neurological Association, International Society for Cerebral Blood Flow and Metabolism and the Society for Neuroscience.

Caracteristici

Covers major causes of nerve cell death including strokes, seizures, etc Material from previous edition has been comprehensively updates Includes 3 new chapters

Recenzii

“This is an outstanding book concerning the molecular and cellular mechanisms of trauma and ischemia in the mammalian brain. … I recommend his book to neurophysiologists, neurologists, and neurosurgeons.” (Joseph J. Grenier, Amazon.com, September, 2015)

Textul de pe ultima copertă

This book is the result of a convergence of scientific information regarding mechanisms that produce acute nerve cell death in the brain. Although seemingly disparate, stroke, brain and spinal cord trauma, coma from a low serum glucose concentration (hypoglycemia), and prolonged epileptic seizures have in common the inciting factor of excitotoxicity, the activation of a specific subtype of glutamate receptor by an elevated extracellular glutamate concentration that results in an excessive influx of calcium into nerve cells. The high calcium concentration in nerve cells activates several enzymes that are responsible for degradation of cytoplasmic proteins and cleavage of nuclear DNA, resulting in nerve cell death. The high calcium concentration also interferes with mitochondrial respiration, with the resultant production of free radicals that damage cellular membranes and nuclear DNA. Understanding the biochemical pathways that produce nerve cell death is the first step toward devising an effective neuroprotective strategy, the ultimate goal.
Acute Neuronal Injury will be useful to neuroscientists and general cell biologists interested in cell death. The book will also be helpful to clinically oriented neuroscientists, including neurologists, neurosurgeons and psychiatrists.
About the Editor:
Dr. Denson Fujikawa is an Adjunct Professor of Neurology at the David Geffen School of Medicine at UCLA, a member of the Brain Research Institute at UCLA and a Sta
ff Neurologist at the Department of Veterans Affairs Greater Los Angeles Healthcare System. His interest in mechanisms of nerve cell death in the brain began during a two-year epilepsy research fellowship with Dr. Claude Wasterlain, from 1981 to 1983. He is a Fellow of the American Academy of Neurology and is a member of the American Epilepsy Society, American Neurological Association, International Society for Cerebral Blood Flow and Metabolism, and the Society for Neuroscience.