Adrenocortical Carcinoma de Gary D. Hammer

Adrenocortical Carcinoma: Basic Science and Clinical Concepts

Gary D. Hammer

Tobias Else

en Limba Engleză Paperback – 18 aug 2014

We anticipate the book to be a definitive text on the subject that explores all aspects of the study of adrenal cancer and the treatment of patients with the disease. Chapters will cover epidemiology, pathogenesis, genetics, cancer stem cells, historic and emerging therapies, mouse models of adrenal cancer, new developments in tumor profiling, worldwide collaborative groups and tumor registries together with resources for the practitioner and community of adrenal cancer scientists.
We do not wish this book to compete with the other larger books in the Endocrine and Endocrine Surgery literature. In addition, it is not expected to cover benign adrenal diseases that have been covered in detail in other venues. We envision this book to be a very specialized and exhaustive text on basic, translational and clinical aspects of adrenal cancer.

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	Preț	Express
Paperback (1)	1395^.41 lei 43-57 zile
Springer – 18 aug 2014	1395^.41 lei 43-57 zile
Hardback (1)	1400^.44 lei 43-57 zile
Springer – 23 noi 2010	1400^.44 lei 43-57 zile

Cuprins

Preface1. History of ACC Research and Clinical Care 1.1. ACC - A 50 year retrospective view1.2. History of ACC Treatment – A Surgical Perspective2. Epidemiology, Presentation and Diagnosis2.1. Epidemiology2.2. Presentation and Diagnosis2.3. Approach to the Adrenal incidentaloma 3.0. Imaging 3.1. Anatomic imaging3.2. Functional imaging4. Pathology4.1. ACC Histopathology4.2. Molecular and Cellular Pathology5. Genetic & Molecular Aspects of ACC5.1. Overview of the Genetics of ACC5.2. Li Fraumeni Syndrome5.3. P53 Molecular Genetics5.4. Telomeres and ACC5.5. Beckwith Wiedemann Syndrome5.6. Insulin-like growth Factors5.7. Wnt signaling6. Models of Adrenocortical Cancer6.1. Cellular origin and identity of ACC 6.2. Adrenocortical cell lines6.3. Mouse Models of Adrenal Tumorigenesis7. Therapies7.1. Introduction7.2. Mitotane7.3. Cytotoxic Chemotherapy7.4. Steroidogenesis and Therapy of Hormone Excess7.5. Surgical therapy7.6. Radiation Therapy7.7. Surveillance and follow up of ACC8 Unique ACC Cohorts and Future Perspectives8.1.. Aldosterone producing ACC8.2. Childhood ACC8.3. Molecular Profiling of Adrenal Cancer8.4. Clinical Registries: Dutch and European experiences8.5. Emerging Strategies

Textul de pe ultima copertă

This first edition of the textbook “Adrenocortical Carcinoma: Basic Sciences and Clinical Concepts” provides a concise compilation of relevant data advancing our current understanding of this rare cancer. Chapters are dedicated to various aspects of both the basic biology and the clinical science relating to adrenocortical carcinoma (ACC). Expert clinicians introduce the reader to current state-of-the-art clinical care of patients with ACC. As a considerable body of knowledge on ACC has accumulated over the last decades, expert scientists have authored additional sections that serve as a reference source for the experienced researcher as well as an introduction for the trainee in the laboratory or clinic.Clinical topics span the epidemiology, diagnosis and therapy of ACC. Scientific topics areas span the pathology and pathophysiology of ACC with a special focus on experimental models of adrenocortical tumors and recent advances in the genetic aspects and signaling pathways in ACC. The content of this book was compiled and edited with the intent of facilitating the translation of knowledge into future diagnostic and therapeutic tools that will ultimately improve patient care.