Advances in Antiviral Drug Design de E. De Clercq

Advances in Antiviral Drug Design: Advances in Antiviral Drug Design, cartea 5

en Limba Engleză Hardback – 29 iul 2007

Regularly reviewing the "state-of-the-art" developments in the antiviral drug research field, this latest volume spans the conceptual design and chemical synthesis of new antiviral compounds. It discusses their structure-activity relationship, mechanism and targets of action, pharmacological behavior, antiviral activity spectrum, and therapeutic potential for clinical use.

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Specificații

ISBN-13: 9780444521736
ISBN-10: 0444521739
Pagini: 264
Ilustrații: 1
Dimensiuni: 152 x 229 x 16 mm
Greutate: 0.58 kg
Ediția:Revised.
Editura: ELSEVIER SCIENCE
Seria Advances in Antiviral Drug Design

Public țintă

Researchers, academics and postgraduates working in medical virology and infectious diseases, chemotherapy and drug discovery

Cuprins

Status presens of antiviral drugs and strategies, Part I: DNA viruses and retroviruses
Status presens of antiviral drugs and strategies, Part II: RNA viruses (except retroviruses)
Methylenecyclopropane analogues of nucleosides as anti-herpes agents
Synthesis and antiviral evaluation of broad spectrum orally active analogs of cidofovir and other acyclic nucleoside phosphonates
CCR5 antagonists for the treatment of HIV infection and AIDS
The medicinal chemistry of the DATA and DAPY series of HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs)

Recenzii

"All six chapters in the current volume are up-to-date, interesting reading, and written by experts on each subject...The first chapter on "New Anti-HIV Agents in Preclinical or Clinical Development" is written by the editor, who is a recognized authority in this area. It is an excellent overview of current advances in the clinic and laboratory. Not only does this review thoroughly cover drugs acting by conventional mechamisms, such as reverse transcriptase and protease inhibition, it also details agents operating by novel mechanisms...A highlight of the volume is the chapter by Gilead co-workes Jin and Kim entitled "Design of Neuraminidase Inhibitors as Anti-Influenza Virus Agents". This is an excellent description of the medical chemistry of an important new class of antiviral drugs based on enzyme X-ray structures and structure-activity relationships...it provides very useful information and it is thorough in some areas...it should be an essential acquisition for complete libraries in academic institutions and pharmaceutical companies." --Thomas W. Bell, University of Nevada, Reno for JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol. 126, 2004

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