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Aging and Heart Failure: Mechanisms and Management

Editat de Bodh I. Jugdutt
en Limba Engleză Paperback – 2 sep 2016
This book synthesizes the major research advances in molecular, biochemical and translational aspects of aging and heart failure over the last four decades and addresses future directions in management and drug discovery. It presents clinical issues and molecular mechanisms related to heart failure, including the changing demographics in the aging population with heart failure; hypertension and prevention of diastolic heart failure in the aging population; polypharmacy and adverse drug reactions in the aging population with heart failure; changes in the heart that accompany advancing age from humans to molecules; aging-associated alterations in myocardial inflammation and fibrosis and aging-related changes in mitochondrial function and implications for heart failure therapy. The book succinctly summarizes the large volume of data on these key topics and highlights novel pathways that need to be explored. Featuring contributions from leading clinician-scientists, Aging and Heart Failure: Mechanisms and Management is an authoritative resource on the major clinical issues in heart failure therapy in the elderly for cardiologists, gerontologists and internists.
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Specificații

ISBN-13: 9781493944231
ISBN-10: 1493944231
Pagini: 497
Ilustrații: XXII, 475 p. 84 illus., 50 illus. in color.
Dimensiuni: 178 x 254 mm
Greutate: 0 kg
Ediția:Softcover reprint of the original 1st ed. 2014
Editura: Springer
Colecția Springer
Locul publicării:New York, NY, United States

Cuprins

Ch. 1: Changing demographics of the aging population with heart failure and implications for therapy
            Bodh I. Jugdutt
Ch. 2: Biology of aging and implications for heart failure therapy and prevention
            Bodh I. Jugdutt
Ch. 3: Hypertension and prevention of diastolic heart failure in the aging population
            Wilbert S. Aronow
Maciej Banach
Ali Ahmed
Ch. 4: Aging and optimal therapy of systolic heart failure in the elderly
            Nakul Chander Sharma
Bodh I. Jugdutt
 
Ch. 5: Atrial fibrillation and heart failure in the aging population
            Pedram Kazemian
Bodh I. Jugdutt
Ch. 6: Optimizing therapy of heart failure in the aging population with monitoring in clinics
            John R. Dimitry
Justin A. Ezekowitz
Ch. 7:  Cardiac alterations in aging, hypertension and diastolic heart failure
            Edith Pituskin
D. Ian Paterson
Ch. 8: Polypharmacy and adverse drug reactions in the aging population with heart failure
            Michael W. Rich
William J. Nienaber
Ch. 9: Aging-related changes in vascular biology and implications for heart failure therapy in the aging population
            Michael Sean McMurtry
Ch. 10: Biomarkers and optimal management of heart failure in the aging population
            Hanna K. Gaggin
James L. Januzzi, Jr.
Ch. 11: Benefits of Exercise in the elderly
            Ezra A. Amsterdam
C. Tissa Kappagoda
Ch. 12: The RAAS in heart failure: an update on clinical trials and opportunities for therapy
            C. Tissa Kappagoda
Ezra A. Amsterdam
Ch. 13: Aging and diastolic dysfunction – the interplay of inflammation and extracellular matrix regulation        
            Peter Moritz Becher
Dirk Westermann,
Carsten Tschöpe
Ch. 14: Reperfusion and vasodilator therapy in elderly patients with STEMI and heart failure. Improving outcomes
Bodh I. Jugdutt,
Anwar Jelani
Seraj Abualnaja
Nakul Chander Sharma
Joseph Szeman Wong
Ch. 15: Erythropoietin therapy for heart failure
            Margarita Borovka
Mathew S. Maurer
Ch. 16: Role of resistin in heart failure in the elderly
            Yasuchika Takeishi
Ch. 17: Role of coronary artery calcium in cardiovascular risk stratification and management in the aging population
            Craig R. Butler
Paolo Raggi
Ch. 18: Aging-and remodeling of the RAS and RAAS and related pathways. Implications for heart failure therapy
Bodh I. Jugdutt
Ch. 19: Aging and right ventricular failure from pulmonary hypertension: Effect of right ventricular and pulmonary artery remodeling
Joseph Szeman Wong
Bodh I. Jugdutt
Ch. 20: Biomarkers of cardiovascular aging
           Nirankar S. Neki
Paramjit S. Tappia
Naranjan S. Dhalla
Ch. 21: Changes in the heart that accompany advancing age: Humans to molecules
            Edward G. Lakatta
Harold A. Spurgeon
Andzej M. Janczewski
Ch. 22: Aging-related changes in cell death and cell survival pathways and implications for heart failure therapy
            Guido R.Y. De Meyer
Dorien M. Schrijvers
Wim Martinet
Ch. 23: Aging-related changes in telomeres and telomerases and implications for heart failure therapy
            Pim van der Harst
Dirk J. van Veldhuisen
Ch. 24: Aging associated alterations in myocardial inflammation and fibrosis: pathophysiological perspectives and clinical implications
            Arti V. Shinde
Nikolaos G Frangogiannis
Ch. 25: Aging-related changes in extracellular matrix: implications for ventricular remodeling following myocardial infarction 
            Nguyen T. Nguyen
Andriy Yabluchanskiy
Lisandra E. de Castro Brás
Yu-Fang Jin
Merry L. Lindsey
Ch. 26: Calcium handling defects and changes in cardiac function in the aging heart
            Adriana Adameova
Nirankar S. Neki
Paramjit S. Tappia
Naranjan S. Dhalla
Ch. 27: Integrins: Implications for aging in heart failure therapy
            Laura L. Daniel
William L. Joyner
Mahipal Singh
Krishna Singh
Ch. 28: Adipokines as novel biomarkers in aging and heart failure
            Ken Shinmura
Ch. 29: Aging-related changes in cellular and molecular mechanisms of post-infarction remodeling. Implications for heart failure therapy
            Henry Han-Jen Shih
Andrew J. Boyle
Ch. 30: Aging-related changes in mitochondrial function and implication for heart failure therapy
            Satoaki Matoba
Atsushi Hoshino
Hiroaki Matsubara
Ch. 31: Regulation of SERCA via oxidative modifications: Implications for the pathophysiology of diastolic dysfunction in the aging heart
            Fuzhong Qin
Richard A. Cohen
Wilson S. Colucci
Ch. 32: SMP-30 and aging-related cardiac remodeling and heart failure
            Satoshi Suzuki
Yasuchika Takeishi

Textul de pe ultima copertă

This book synthesizes the major research advances in molecular, biochemical, and translational aspects of aging and heart failure over the last four decades and addresses future directions in management and drug discovery. It presents clinical issues and molecular mechanisms related to heart failure, including the changing demographics in the aging population with heart failure; hypertension and prevention of diastolic heart failure in the aging population; polypharmacy and adverse drug reactions in the aging population with heart failure; changes in the heart that accompany advancing age from humans to molecules; aging-associated alterations in myocardial inflammation and fibrosis; and aging-related changes in mitochondrial function and implications for heart failure therapy. The book succinctly summarizes the large volume of data on these key topics and highlights novel pathways that need to be explored. Featuring contributions from leading clinician-scientists, Aging and Heart Failure: Mechanisms and Management is an authoritative resource on the major clinical issues in heart failure therapy in the elderly for cardiologists, gerontologists, and internists.

Caracteristici

Valuable resource on molecular mechanisms of heart failure related to aging and current status of therapies for heart failure in the elderly
Provides critical assessment of publications on key topics by leading investigators in the field with emphasis on translational research and therapeutic implications
Addresses potential novel strategies that should receive attention for translating basic research knowledge into clinical application in patients
Includes supplementary material: sn.pub/extras