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Alagille Syndrome: Pathogenesis and Clinical Management de Binita M. Kamath

Alagille Syndrome: Pathogenesis and Clinical Management

Editat de Binita M. Kamath, Kathleen M. Loomes
en Limba Engleză Hardback – 9 oct 2018
This text provides a concise yet comprehensive overview of Alagille syndrome. The book reviews the pathophysiology and genetics of the disorder, discusses recent molecular advances and its impact on diagnostics, and describes management challenges and strategies. The text also touches upon future treatment options.

Written by experts in the field, Alagille Syndrome: Pathogenesis and Clinical Management is a valuable resource for physicians and researchers dealing with this disorder, one that will help guide patient management and stimulate investigative efforts.  
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Specificații

ISBN-13: 9783319945705
ISBN-10: 331994570X
Pagini: 244
Ilustrații: XIV, 198 p. 41 illus., 31 illus. in color.
Dimensiuni: 155 x 235 mm
Greutate: 0.57 kg
Ediția:1st ed. 2018
Editura: Springer International Publishing
Colecția Springer
Locul publicării:Cham, Switzerland

Cuprins

The Alagille Syndrome: Overview and Introduction.- Bile Duct Development and the Notch Signaling Pathway.- Genetics of Alagille Syndrome.- Liver Disease in Alagille Syndrome.- Transplant Considerations in Alagille Syndrome.- Cardiac, Aortic, and Pulmonary Vascular Involvement in Alagille Syndrome.- Vascular Manifestations in Alagille Syndrome.- The Renal Sequelae of Alagille Syndrome as a Product of Altered Notch Signaling During Kidney Development.- Skeletal Involvement in Alagille Syndrome.- Immune Dysregulation in Alagille Syndrome: A Feature of the Evolving Phenotype.- Health-Related Quality of Life and Neurocognition in Alagille Syndrome.- Future Therapeutic Approaches for Alagille Syndrome.

Notă biografică

Binita M. Kamath, MBBChir MRCP MTR
The Hospital for Sick Children
Division of Gastroenterology, Hepatology and Nutrition 
Toronto, ON
Canada

Kathleen M. Loomes, MD
Children’s Hospital of Philadelphia
Division of Gastroenterology, Hepatology and Nutrition
Department of Pediatrics
Philadelphia, PA
USA
 

Textul de pe ultima copertă

This text provides a concise yet comprehensive overview of Alagille syndrome. The book reviews the pathophysiology and genetics of the disorder, discusses recent molecular advances and its impact on diagnostics, and describes management challenges and strategies. The text also touches upon future treatment options.

Written by experts in the field, Alagille Syndrome: Pathogenesis and Clinical Management is a valuable resource for physicians and researchers dealing with this disorder, one that will help guide patient management and stimulate investigative efforts.  

Caracteristici

Provides a concise yet comprehensive overview of Alagille syndrome Outlines management challenges, strategies, and future treatment options Written by experts in the field