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Alkaloids: Chemical and Biological Perspectives: Alkaloids: Chemical and Biological Perspectives, cartea 12

Editat de S.W. Pelletier
en Limba Engleză Hardback – 23 apr 1998
Acronycine, a potent antitumor agent, was discovered in the bark of the small Australian Rutaceous tree, Acronychia baueri Schott. This new work presents a comprehensive survey of the isolation, structure determination, methods of synthesis, and the biological properties of acronycine, as well as an account of natural and synthetic analogues of acronycine, and their biological properties.

Solanum alkaloids were reviewed in 1990 and this book surveys the new developments (isolation procedures, structural elucidation methods) and critically updates earlier reviews.
In addition it presents the interesting chemistry and synthesis of cyclopeptide alkaloids. These cyclopeptide alkaloids have been isolated from ascidians, sea hares, and cyanobacteria.
Also included are reviews of the use of the functionalized lactam, pyroglutamic acid, as a chiral template for the synthesis of alkaloids.
The second review examines the on-line coupling of capillary electrophoresis (CE) and mass spectrometry (MS) for the analysis of alkaloid mixtures.
Finally a review of oxygenated analogs of the alkaloid Marcfortine for their potent antiparasitic activity is included at the end of this work.

Each chapter in this volume has been reviewed by at least one expert in the field. Indexes for both subjects and organisms are provided.
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Specificații

ISBN-13: 9780080428055
ISBN-10: 0080428053
Pagini: 387
Dimensiuni: 156 x 234 x 24 mm
Greutate: 0.74 kg
Editura: ELSEVIER SCIENCE
Seria Alkaloids: Chemical and Biological Perspectives


Cuprins

Acronycine-type alkaloids: chemistry and biology (F. Tillequin et al.). Solanum steroid alkaloids - an update (H. Ripperger). Synthesis and structure-activity studies of Lissoclinum peptide alkaloids (P. Wipf). Pyroglutamate as a chiral template for the synthesis of alkaloids (M.B. Smith). Analysis of alkaloids by capillary electrophoresis and capillary electrophoresis - electrospray mass spectrometry (J. Stöckigt et al.). Oxidation of anthelmentic marcofortine A, an indole alkaloid (B.H. Lee et al.). Subject index. Organism index.

Recenzii

from:Geoffrey A. Cordell
"This is the eleventh in the series of volumes intitiated in 1983 to complement The Alkaloids: Chemistry and Pharmacology series of Academic Press. This particular volume brings together five chapters, one major contribution from Paul Schiff and four shorter contributions from a distinguished group of authors, which collectively maintain the quality of the series. Schiffs' marvellous tour-de-force demonstrates his preeminent knowledge of the alkaloids of Thalictrum species, and it is both refreshing and inspiring to see the wealth of data on these diverse alkaloid groups presented in such a lucid and well-organised manner....Overall this volume is strongly recommended for university and corporate libraries..." --Journal of Natural Products