In this issue of Physical Medicine and Rehabilitation Clinics, guest editors Drs. Alex Donaghy and Alberto Miranda bring their considerable expertise to the topic of Amputee Rehabilitation. Focusing on advancements and innovations in the field, this issue presents evidence-based reviews and clinical insights from physicians, therapists, and prosthetist/orthotists practicing in a variety of clinical settings. Through these expert perspectives, readers will gain insight into promoting better rehabilitation outcomes and fostering a more inclusive and supportive society for those with limb deficiency.