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An introduction to genetic epidemiology: Health and Society

Autor Lyle J. Palmer
en Limba Engleză Paperback – 30 mai 2011
Genetic epidemiology is a very rapidly developing field that has acquired a central role in modern biomedical science. Until now there has been no comprehensive introductory text for students and academics who do not have specialised training in statistics or genetics. This book begins with a primer in human molecular genetics and then examines standard methods in population genetics and genetic epidemiology required for an adequate grounding in the field. Among much else, the book contains discussion of the public health aspects of the new genetics, and of epidemiological methods for studying genes and environmental factors in complex diseases. Written by leading international experts and supplemented by a glossary and in-chapter guides to further reading, this essential textbook will be widely welcomed by teachers and students on many courses internationally.
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Specificații

ISBN-13: 9781861348975
ISBN-10: 1861348975
Pagini: 256
Ilustrații: black & white tables, diagrams, figures, charts, graphs
Dimensiuni: 172 x 240 x 13 mm
Greutate: 0.41 kg
Editura: Bristol University Press
Seria Health and Society

Locul publicării:United Kingdom

Recenzii

This book should be incredibly useful to students and researchers at all levels in genetic epidemiology. For students it offers an eminently readable and accessible foundation, and for researchers, a superb source to fill in missing pieces in our knowledge. Ezra Susser, Professor of Epidemiology and Psychiatry, Mailman School of Public Health, Columbia University, and New York State Psychiatric Institute

This is a sobering must-read for anyone who wishes to know how genetic epidemiology may change how we understand, treat or prevent human disease. Robert Elston, Case Western Reserve University School of Medicine

Notă biografică

Lyle J. Palmer, Western Australian Institute for Medical Research, University of Western Australia, Paul R. Burton, Department of Health Sciences and Department of Genetics, University of Leicester and George Davey Smith, Department of Social Medicine, University of Bristol

Cuprins

List of tables, figures and boxes
Notes on contributors
Acknowledgements
Introduction
      Lyle J. Palmer, Paul R. Burton, and George Davey Smith

1. Key concepts in genetic epidemiology
      Paul R. Burton, Martin D. Tobin, and John L. Hopper
2. Genetic linkage studies
      M. Dawn Teare and Jennifer H. Barrett
3. Genetic association studies
      Heather J. Cordell and David G. Clayton
4. Mapping complex disease genes using linkage disequilibrium and genome-wide association scans
      Lyle J. Palmer, Nicholas J. Timpson, David M. Evans, George Davey Smith, and Lon R. Cardon
5. A question of standards: what makes a good genetic association study?
      Andrew T. Hattersley and Mark I. McCarthy
6. Biobanks and biobank harmonisation
      Paul R. Burton, Isabel Fortier, Mylene Deschênes, Anna Hansell, and Lyle J. Palmer
7. Population health aspects of genetic epidemiology: genomic profiling, personalised medicine, and Mendelian randomisation
      George Davey Smith, Shah Ebrahim, Sarah Lewis, and Lyle J. Palmer

Glossary
Index