Analysis of Complex Disease Association Studies: A Practical Guide
Editat de Eleftheria Zeggini, Andrew Morrisen Limba Engleză Hardback – 17 noi 2010
This burgeoning science merges the principles of statistics and genetics studies to make sense of the vast amounts of information available with the mapping of genomes. In order to make the most of the information available, statistical tools must be tailored and translated for the analytical issues which are original to large-scale association studies. Analysis of Complex Disease Association Studies will provide researchers with advanced biological knowledge who are entering the field of genome-wide association studies with the groundwork to apply statistical analysis tools appropriately and effectively. With the use of consistent examples throughout the work, chapters will provide readers with best practice for getting started (design), analyzing, and interpreting data according to their research interests. Frequently used tests will be highlighted and a critical analysis of the advantages and disadvantage complimented by case studies for each will provide readers with the information they need to make the right choice for their research. Additional tools including links to analysis tools, tutorials, and references will be available electronically to ensure the latest information is available.
- Easy access to key information including advantages and disadvantage of tests for particular applications, identification of databases, languages and their capabilities, data management risks, frequently used tests
- Extensive list of references including links to tutorial websites
- Case studies and Tips and Tricks
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Specificații
ISBN-13: 9780123751423
ISBN-10: 012375142X
Pagini: 340
Ilustrații: Illustrated
Dimensiuni: 152 x 229 x 23 mm
Greutate: 0.73 kg
Editura: ELSEVIER SCIENCE
ISBN-10: 012375142X
Pagini: 340
Ilustrații: Illustrated
Dimensiuni: 152 x 229 x 23 mm
Greutate: 0.73 kg
Editura: ELSEVIER SCIENCE
Public țintă
Geneticists, biologists, epidemiologists, and biostatisticians moving into the field of complex disease genetics who do not have formal statistical training, or previous experience of analyzing similar data; biostatistics, statistical genetics, and advanced human genetics students; drug company biostatisticiansCuprins
Chapter 1 Genetic architecture of complex disease
Chapter 2 Population genetics and linkage disequilibrium
Chapter 3 Genetic association study design
Chapter 4 Selection of SNPs
Chapter 5 Genotype calling
Chapter 6 Data handling
Chapter 7 Data quality control
Chapter 8 Single-locus tests of association for population-based studies
Chapter 9 Population structure
Chapter 10 Haplotype-based methods
Chapter 11 Interaction analyses
Chapter 12 Copy number variant analysis
Chapter 13 Analysis of family-based association studies
Chapter 14 Bioinformatics approaches
Chapter 15 Interpreting association signals
Chapter 16 Delineating association signals
Chapter 17 Case study: obesity
Chapter 18 Case study: rheumatoid arthritis
Chapter 2 Population genetics and linkage disequilibrium
Chapter 3 Genetic association study design
Chapter 4 Selection of SNPs
Chapter 5 Genotype calling
Chapter 6 Data handling
Chapter 7 Data quality control
Chapter 8 Single-locus tests of association for population-based studies
Chapter 9 Population structure
Chapter 10 Haplotype-based methods
Chapter 11 Interaction analyses
Chapter 12 Copy number variant analysis
Chapter 13 Analysis of family-based association studies
Chapter 14 Bioinformatics approaches
Chapter 15 Interpreting association signals
Chapter 16 Delineating association signals
Chapter 17 Case study: obesity
Chapter 18 Case study: rheumatoid arthritis