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Medical Epigenetics

Editat de Trygve O. Tollefsbol
en Limba Engleză Hardback – 12 iul 2016
Medical Epigenetics provides a comprehensive analysis of the importance of epigenetics to health management. The purpose of this book is to fill a current need for a comprehensive volume on the medical aspects of epigenetics with a focus on human systems, epigenetic diseases that affect these systems and modes of treating epigenetic-based disorders and diseases. The intent of this book is to provide a stand-alone comprehensive volume that will cover all human systems relevant to epigenetic maladies and all major aspects of medical epigenetics. The overall goal is to provide the leading book on medical epigenetics that will be useful not only to physicians, nurses, medical students and many others directly involved with health care, but also investigators in life sciences, biotech companies, graduate students and many others who are interested in more applied aspects of epigenetics. Research in the area of translational epigenetics is a cornerstone of this volume.

  • Critical reviews dedicated to the burgeoning role of epigenetics in medical practice
  • Coverage of emerging topics including twin epigenetics as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine
  • Encompasses a disease-oriented perspective of medical epigenetics as well as diagnostic and prognostic epigenetic approaches to applied medicine
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Specificații

ISBN-13: 9780128032398
ISBN-10: 0128032391
Pagini: 924
Dimensiuni: 216 x 276 x 51 mm
Greutate: 2.77 kg
Editura: ELSEVIER SCIENCE

Cuprins

Section I:  Overview
1.  An Overview of Medical Epigenetics
 Trygve O. Tollefsbol

Section II:  Basic Principles of Epigenetics
2.  DNA Methylation:  Basic Principles
 Cynthia A. Moylan and Susan K. Murphy
3.  Histone-deacetylases as a therapeutic target in neurodegenerative diseases
 Farahnaz Sananbenesi and Andre Fischer
4.  Basic principles of noncoding RNAs in epigenetics
 Ilaria Panzeri, Grazisa Rossetti and Massimiliano Pagani

Section III:  General Medical Aspects of Epigenetics
5.  Epidemiological Epigenetics in Medicine
 Alexander  Vaiserman
6.  Lifestyle and Preventive Medical Epigenetics
 Marcus V. Gomes
7.  Environmental Medical Epigenetics: A Review of Epigenetically-induced Medical Risks Generated from Exposures in Our Air, Food, and Personal Products
 Rachel L. Miller
8.  Behavioral Medical Epigenetics
 Olivia H. Cox and Richard S. Lee
9.  Medical Epigenetics in Twins
 Joel C. Eissenberg
10.  Epigenetic Biomarkers of Disease
 Philip D. Voyias, Abhilasha Patel and Ramesh P. Arasaradnam
11.  Prognostic Epigenetics
 Anup Sharma, Eihab Abdelfatah, Maryam Al Eissa and Nita Ahuja

Section IV:  Epigenetics of System Disorders
12.  Immune System Disorders and Epigenetics
 Stuti Mehta and Kate L. Jeffrey
13.  Pulmonary Diseases and Epigenetics
 Hong Peng, Dandan Zong, Zijing Zhou and Ping Chen
14.  Cardiovascular Disorders and Epigenetics
 Charbel Abi Khalil
15.  Epigenomics of Intestinal Disease
 Daniel Rory Kelly and Theresa Alenghat
16.  Epigenetics of Skin Disorders
 Shuaihantian Luo and Qianjin Lu
17.  Epigenetics in Bone and Joint Disorders
 N. Altorok, S. Nada, V. Nagaraja and Bashar Kahaleh
18.  Epigenetics of Muscle Disorders
 Viviana Moresi, Nicoletta Marroncelli, Eva Pigna and Sergio Adamo
19.  Epigenetics of Psychiatric Disorders
 Marija Kundakovic
20. Epigenetic Alterations in Endocrine-dependent Cancers:  Implications of Endocrine Dysfunctions 
 Genevieve Deblois and Mathieu Lupien
21.  Reproductive Disease Epigenetics
  Rafael Oliva*
22.  Epigenetics in Ocular Medicine
 Verity F. Oliver, Katherine A. van Bysterveldt and Shannath L. Merbs*
Section V:  Multi-system Medical Epigenetics
23.  Pediatric Diseases and Epigenetics
 Judith G. Hall*
24.  Epigenetics of Infectious Diseases
 Kate L. Seib and Michael P. Jennings
25.  Clinical Utility of Solid Tumor Epigenetics
 Søren Kristiansen and György Sölétormos
26.  Epigenetic Control in Human Normal Follicular Thyroid Cells and in Thyroid Carcinoma
 Zeus Andrea Antonello and Carmelo Nucera
27.  Epigenetics in Acute Myeloid Leukemia
 Cristina Giorgio, Carmela Dell’Aversana and Lucia Altucci
28.  Epigenetic Regulation in Cancer Metastasis
 Huan Wang, Yukun Zhang, Adam Kriska and Hong Chen
29.  Epigenetics in Exercise Science and Sports Medicine
 Philipp Zimmer, Alexander Schenk and Wilhelm Bloch
30.  Epigenetic Mechanisms and Inheritance of Acquired Susceptibility to Disease
 Rajesh C. Miranda, Nihal A. Salem, Annette S. Fincher, Amanda H. Mahnke and Sasha G. Burrowes

Section VI.  Pharmacology of Epigenetics
31.  Toxicology and Epigenetics
 Jian Tajbakhsh and Jatinder Singh
32.  Pharmacoepigenomics
 Ramón Cacabelos and Clara Torrellas

Section VII:  Therapeutic Epigenetics
33.  Therapeutics and DNA Methylation Inhibitors
 Sheena Bhalla and Shyamala C. Navada
34.  Histone Deacetylase Inhibitors in Medical Therapeutics
 Pusoon Chun
35.  NAD+-dependent Deacetylases and Medical Therapy
 Ashok Kumar, Louisa Ben-Aderet, Jinan Elayan and Mona Dvir-Ginzberg*
36.  Experimental Approaches Towards Histone Acetyltransferase Inhibitors as Therapeutics
 H. Wapenaar and Frank J. Dekker
37.  Histone Methylation Modifiers in Medical Therapeutics
 Patrick Trojer
 
38.  Therapeutics of Epigenetic-based RNA molecules
 Costas Koufaris* and Vicky Nicolaidou
39.  Natural Epigenetic-modifying Molecules in Medical Therapy
 Avinash Kumar, Nasir A. Butt and Anait S. Levenson
40.  Outcome of Combining Epigenetic Drugs with Other Treatments in the Clinic
 Paromita Raha
41.  Epigenetics of Pain Management
 Beverley Greenwood-Van Meerveld, Dawn Prusator, Casey Ligon, Anthony C. Johnson and Rachel D. Moloney
42.  Personalized Epigenetics
 Michael Bitzer and Nisar P. Malek
43.  Epigenetics and Regenerative Medicine: Neural and Skeletal Muscle Perspectives
 Constantin Heil and Daniela Palacios
44.  Stem Cell Epigenetics in Medical Therapy
 Baoli Cheng, Liqi Shu and Peng Jin

Section VIII:  Medical Epigenetics:  Future Prospects
45.  Prospective Advances in Medical Epigenetics
 Junjie Xiao and Guoping Li