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Analysis of Pharmaceuticals by Capillary Electrophoresis: CHROMATOGRAPHIA CE-Series, cartea 2

Autor Kevin D. Altria
en Limba Engleză Paperback – 9 feb 2012
During the 1980's the analysis of pharmaceuticals was dominated by the use of High Perfor­ mance Liquid Chromatography (HPLC). Other separative techniques such as Gas Chromato­ graphy and Thin Layer Chromatography offered alternatives but their quantitative capabili­ ties and/or solute range could not approach that of HPLC. The majority of pharmaceuticals are ionic and it would be reasonable to assume that electrophoresis may be useful in the analysis of pharmaceuticals. However, the electrophore­ tic instruments available in the 1980's were labour intensive and employed post-separation detection procedures. During the late 1980's and early 1990's extensive research was con­ ducted into the possibilities of conducting electrophoretic separations in capillaries. This approach allowed on-line detection and could be performed on fully automated equipment. This research led to the advent of modern day capillary electrophoresis (CE) instruments which offer similar performance and automation levels to that of HPLC. Research was also focused on developing applications for CE and particular attention was paid to applications within the pharmaceutical analysis area. These applications proved that CE could be applied to a wide range of drug types including water insoluble and neutral compounds. The ability to achieve efficient chiral separations of drugs also increased the popularity of the technique. CE with indirect UV detection has become established as a simple and effective alternative to ion-exchange chromatography for the determination of small inorganic or organic ions.
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Specificații

ISBN-13: 9783322850133
ISBN-10: 3322850137
Pagini: 304
Ilustrații: XII, 285 p.
Dimensiuni: 170 x 240 x 16 mm
Greutate: 0.49 kg
Ediția:Softcover reprint of the original 1st ed. 1998
Editura: Vieweg+Teubner Verlag
Colecția Vieweg+Teubner Verlag
Seria CHROMATOGRAPHIA CE-Series

Locul publicării:Wiesbaden, Germany

Public țintă

Professional/practitioner

Cuprins

General introduction to CE principles, instrumentation and methodology - Determination of drug related impurities - Main component assay - Chiral separations - Drug counter-ion determinations - Identity confirmation testing - Clinical applications - Trace level determination of drugs and surfactants - Analysis of excipients and raw materials by CE - Analysis of biopharmaceuticals - Method performance optimization guidelines - Method validation - Critical comparison of CE with HPLC for pharmaceutical analysis - Miscellaneous: electrochromatography, vitamin analysis, radiopharmaceutical analysis, micro-preprative CE

Recenzii

"Das Buch bietet dem pharmazeutischen Chemiker eine gute Übersicht über die Möglichkeiten, die Kapillarelektrophorese für pharmazeutische Analysen einzusetzen, aber sich auch über deren Grundlagen und Entwicklungsmöglichkeiten zu informieren." (Fresenius Journal of Analytical Chemistry Nr. 1/99)

Notă biografică

Dr. Kevin D. Altria ist Wissenschaftler bei der Glaxo Company in Großbritannien.

The author, Dr. Kevin D. Altria, has been working in Glaxo Wellcome R & D for 10 years. During this time he has developed and implemented many routine pharmaceutical analysis CE methods.