Applications of Enzyme Biotechnology de Jeffrey W. Kelly

Applications of Enzyme Biotechnology: Industry-University Cooperative Chemistry Program Symposia

Jeffrey W. Kelly

Thomas O. Baldwin

The Industry-University Cooperative Chemistry Program (IUCCP) has sponsored eight previous international symposia covering a range of topics of interest to industrial and academic chemists. The ninth IUCCP Symposium, held March 18-21, 1991 at Texas A&M University was the second in a two part series focusing on Biotechnology. The title for this Symposium "Applications of Enzyme Biotechnology" was by design a rather all encompassing title, similar in some respects to the discipline. Biotechnology refers to the application of biochemistry for the development of a commercial product. Persons employed in or interested in biotechnology may be chemists, molecular biologists, biophysicists, or physicians. The breadth of biotech research projects requires close collaboration between scientists of a variety of backgrounds, prejudices, and interests. Biotechnology is a comparatively new discipline closely tied to new developments in the fields of chemistry, biochemistry, molecular biology and medicine. The primary function of Texas A&M University is to educate students who will be appropriately trained to carry out the mission of biotechnology. The IUCCP Symposium serves as an important forum for fostering closer ties between academia and industry and exchanging ideas so important to this evolving area.

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Cuprins

Minisymposium on Diagnostic Therapeutic Applications of Radiolabeled Antibodies.- Radiolabeled Antibodies: Introduction and Metal Conjugation Techniques.- Methods for the Radiohalogenation of Antibodies.- Diagnosis and Therapy of Brain Tumors Utilizing Radiolabeled Monoclonal Antibodies.- Selective Functionalization of Alkanes by Enzymes and Their Models.- Oxygenation by Methane Monooxygenase: Oxygen Activation and Component Interactions.- Structure and Mechanism of Action of the Enzyme(s) Involved in Methane Oxidation.- Studies of Methane Monooxygenase and Alkane Oxidation Model Complexes.- Relevance of Gif Chemistry to Enzyme Mechanisms.- Protein Folding and Refolding for Commercially Important Proteins.- Transthyretin Acid Induced Denaturation Is Required for Amyloid Fibril Formation in Vitro.- Isolation and Characterization of Natural and Recombinant Cyclophilins.- Mutations Affecting Protein Folding and Misfolding in Vivo.- Protein Folding: Local Structures, Domains, and Assemblies.- Environmental Biotechnology.- Applications of Controlled Pore Inert Materials as Immobilizing Surfaces for Microbial Consortia in Wastewater Treatment.- Organophosphorus Cholinesterase Inhibitors: Detoxification by Microbial Enzymes.- Applications of Molecular Biology Techniques to the Remediation of Hazardous Waste.- Dehalogenation of Organohalide Pollutants by Bacterial Enzymes and Coenzymes.- Protein Processing—New Techniques.- Immobilized Artificial Membrane Chromatography: Surface Chemistry and Applications.- Perfusion Chromatography: Recent Developments and Applications.- High Performance Capillary Electrophoresis of Proteins and Peptides: A Minireview.- Genetic Alterations Which Facilitate Protein Purification: Applications in the Biopharmaceutical Industry.- Expression Systems—Exogenous Proteins.- Bacillus subtilis: A Model System for Heterologous Gene Expression.- Aspergillus niger var. awamori as a Host for the Expression of Heterologous Genes.- Poxvirus Vectors: Mammalian Cytoplasmic-Based Expression Systems.