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Applications of Transition Metal Catalysis in Drug Discovery and Development – An Industrial Perspective

Autor ML Crawley
en Limba Engleză Hardback – 25 iul 2012
This book focuses on the drug discovery and development applications of transition metal catalyzed processes, which can efficiently create preclinical and clinical drug candidates as well as marketed drugs. The authors pay particular attention to the challenges of transitioning academically-developed reactions into scalable industrial processes. Additionally, the book lays the groundwork for how continued development of transition metal catalyzed processes can deliver new drug candidates. This work provides a unique perspective on the applications of transition metal catalysis in drug discovery and development - it is a guide, a historical prospective, a practical compendium, and a source of future direction for the field.
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Specificații

ISBN-13: 9780470631324
ISBN-10: 0470631325
Pagini: 384
Dimensiuni: 163 x 234 x 24 mm
Greutate: 0.66 kg
Editura: Wiley
Locul publicării:Hoboken, United States

Public țintă

Organic, medicinal, and process chemists in industry and academia, graduate courses in organic, organometallic, medicinal, synthetic chemistry; drug discovery

Cuprins


Notă biografică

MATTHEW L. CRAWLEY, PhD, is the Director of the Community Physician Electronic Medical Records Program at Main Line Health. Previously, he has worked as a medicinal chemist at Pfizer and Wyeth Research. Dr. Crawley is an author of more than twenty publications, and his discoveries have resulted in several patents. BARRY M. TROST, PhD, is Tamaki Professor of Humanities and Sciences in the Department of Chemistry at Stanford University. Dr. Trost has been elected a Fellow of the American Academy of Sciences and member of the National Academy of Sciences. He has served as chairman of the NIH Medicinal Chemistry Study Section, held over 120 university lectureships, and presented over 260 plenary lectures at national and international meetings.

Descriere

This book documents examples of transition metal catalysis in drug discovery and development from an industrial perspective. Co-edited by Barry Trost, one of the foremost organic research chemists, the authors pay particular attention to transitioning academically-developed reactions into scalable industrial processes.