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Dermal Drug Selection and Development: An Industrial Perspective de Lionel Trottet

Dermal Drug Selection and Development: An Industrial Perspective

Autor Lionel Trottet, Howard Maibach, MD
en Limba Engleză Hardback – 16 aug 2017
The authors show how the pharmaceutical industry faces the development of dermal drugs and provide the only book of its kind that describes how the industry develops and selects dermal drugs, complete with the challenges and opportunities of the field. Delivery of drugs through the skin has been an attractive and challenging area for research, and advances in modern technologies have resulted in a larger number of drugs being delivered transdermally, including conventional hydrophobic small molecule drugs, hydrophilic drugs and macromolecules. Offering the perspective from the industrial side of selection and development of drugs, the primary audience is geared towards the pharmaceutical industry but can also offer valuable information to clinicians, compounding pharmacists, and similarly pharmacy students. Dermal Drug Selection and Development covers the
scientific gaps that exist in terms of dermal pharmacokinetics and the resulting uncertainty by clinicians when choosing a drug candidate.
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Specificații

ISBN-13: 9783319595030
ISBN-10: 3319595032
Pagini: 146
Ilustrații: XVI, 148 p. 53 illus., 35 illus. in color.
Dimensiuni: 155 x 235 mm
Greutate: 0.41 kg
Ediția:1st ed. 2017
Editura: Springer International Publishing
Colecția Springer
Locul publicării:Cham, Switzerland

Cuprins

Introduction.- Choosing the topical drug candidate.- Key factors affecting the efficacy of a topical drug candidate.- Topical vs. Oral/systemic Drug discovery.- Assessing drug concentration in skin.- Assessing Topical efficacy.- Assessing the therapeutic index.- Topical vehicle selection.- Topical drug development strategies.- Topical drug candidate selection criteria and cascade.- Selecting a dermal drug candidate.- Conclusions and perspectives.

Recenzii

“This book provides some valuable insights into the challenges related to the design and development of dermatopharmaceuticals. As such, this book is expected to be well received by the scientific community involved in this kind of research. … this book should serve as a reference for anyone interested in developing dermatopharmaceuticals. … Written by an expert in drug delivery, this book provides an overview of challenges the industry faces in selecting and developing a dermal product.” (Rahmat M. Talukder, Doody's Book Reviews, September, 2017)

Notă biografică

Lionel Trottet, PhD is a DMPK Unit Manager, Drug Discovery chez Oncodesign in France. He has 20 years of expertise in Dermatology (dermal drug discovery, pharmacokinetics, PK/PD and formulation), 18 years of experience in general pharmacokinetics, drug metabolism and PK/PD, 13 years of experience as a DMPK representative in Drug Discovery projects, and 8 years of experience as a DMPK manager.

Howard Maibach, MD is an expert in contact and occupational dermatitis and sees patients at the Environmental Dermatosis Clinic, which is part of the Dermatology Clinic at University of California, San Francisco (UCSF). His specialty is dermatotoxicology, or skin exposure toxicity; allergies and skin disorders; and dermatopharmacology or the study of medications for skin disorders. Dr. Maibach has been on the editorial board of more than 30 scientific journals and is a member of 19 professional societies including the American Academy of Dermatology, San Francisco Dermatolo
gical Society and the Internal Commission on Occupation Health. He is a professor in the Department of Dermatology at UCSF.

Textul de pe ultima copertă

The authors show how the pharmaceutical industry faces the development of dermal drugs and provide the only book of its kind that describes how the industry develops and selects dermal drugs, complete with the challenges and opportunities of the field. Delivery of drugs through the skin has been an attractive and challenging area for research, and advances in modern technologies have resulted in a larger number of drugs being delivered transdermally, including conventional hydrophobic small molecule drugs, hydrophilic drugs and macromolecules. Offering the perspective from the industrial side of selection and development of drugs, the primary audience is geared towards the pharmaceutical industry but can also offer valuable information to clinicians, compounding pharmacists, and similarly pharmacy students. Dermal Drug Selection and Development covers the
scientific gaps that exist in terms of dermal pharmacokinetics and the resulting uncertainty by clinicians when choosing a drug candidate.

Caracteristici

The only book of its kind that describes how the industry develops and selects dermal drugs, complete with its challenges and opportunities Discusses how the science can be used for increased success by clinicians when working with their patients and the abundance of new targets for dermatology Covers the scientific gaps that exist in terms of dermal pharmacokinetics and the resulting uncertainty by clinicians when choosing a drug candidate Includes supplementary material: sn.pub/extras