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Handbook of Drug Metabolism, Third Edition de Paul G. Pearson

Handbook of Drug Metabolism, Third Edition: Drugs and the Pharmaceutical Sciences

Editat de Paul G. Pearson, Larry C. Wienkers
en Limba Engleză Paperback – 31 mar 2021
This book continues to be the definitive reference on drug metabolism with an emphasis on new scientific and regulatory developments. It has been updated based on developments that have occurred in the last 5 years, with new chapters on large molecules disposition, stereo-selectivity in drug metabolism, drug transporters and metabolic activation of drugs. Some chapters have been prepared by new authors who have emerged as subject area experts in the decade that has passed since publication of the first edition.


Key Features:




  • Continues to be the definitive reference on drug metabolism


  • Covers the drug transporter field, disposition of protein therapeutics and metabolic activation of drugs


  • Includes the contributions of world-class experts in their respective fields


  • Contains the work of editors who are recognized leaders and deep content experts in the field of drug metabolism


  • Emphasizes new scientific and regulatory developments in the field
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Specificații

ISBN-13: 9780367779764
ISBN-10: 0367779765
Pagini: 754
Dimensiuni: 178 x 254 x 38 mm
Greutate: 1.32 kg
Ediția:Nouă
Editura: CRC Press
Colecția CRC Press
Seria Drugs and the Pharmaceutical Sciences

Locul publicării:Boca Raton, United States

Public țintă

Academic and Professional Practice & Development

Cuprins

Fundamental Aspects of Drug Metabolism. Factors Which Affect Drug Metabolism. Technologies to Study Drug Metabolism. Applications of Metabolism Studies in Drug Discovery and Development.

Notă biografică

PAUL G. PEARSON is President and CEO, Pearson Pharma Partners, Westlake Village, California, USA. Dr. Pearson received his Ph.D. in Pharmaceutical Sciences from Aston University, Birmingham, UK. He has had an extensive and successful career in pharmaceutical science, previously serving as Vice President of Pharmacokinetics and Drug Metabolism at Amgen, Inc. and Executive Director of Preclinical Drug Metabolism at Merck & Co, Inc. He is an active member of several international and national professional organizations. Dr. Pearson has contributed to numerous peer-reviewed publications and has been an honored invited lecturer at conferences, society meetings, and symposia on drug development, drug metabolism, and drug discovery. Dr Pearson is actively engaged in the discovery and development of new human therapeutics to make a drammatic difference to the lives of patients.




LARRY C. WIENKERS is Principal Scientist, Wienkers Consulting, Bainbridge Island Washington, USA. Prior to consulting, Dr Wienkers served as Vice President of Pharmacokinetics and Drug Metabolism at Amgen, Inc. and Senior Director of Pharmacokinetics, Dynamics, and Metabolism at Pfizer. He obtained his Ph.D. in Medicinal Chemistry from the University of Washington, Seattle, Washington, USA and in 2014 he was awarded the University of Washington, School of Pharmacy Distinguished Alumni Award in Pharmaceutical Science and Research. Larry is a member of several professional societies, where he has served as Chair of American Society of Pharmacology and Experimental Therapeutics Division of Drug Metabolism and in 2013 was elected as Fellow in the American Association of Pharmaceutical Scientists. Dr. Wienkers has published over 80 peer-reviewed publications and book chapters has been an invited lecturer at conferences and symposia on large and small molecule drug metabolism and drug discovery.

Recenzii

The compendium is split into sections on; Fundamental aspects of drug metabolism, Factors which affect drug metabolism, Technologies to study drug metabolism, and Application of metabolism studies in drug discovery and development. Each chapter is well laid out with clear and useful figures and well referenced. As someone who wanted to know more about this field and having a basic knowledge, this was a good read. The chapters on enzyme inhibition and the genetic basis of variation in drug metabolism and toxicity were particularly good.
-Prof. Dudley E. Shallcross, University of Bristol, UK

Descriere

This book continues to be the definitive reference on drug metabolism with an emphasis on new scientific and regulatory developments. It has been updated based on developments that have occurred in the last 5 years, with new chapters on large molecules disposition, stereo-selectivity in drug metabolism, drug transporters and metabolic activation