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Polymorphism in Pharmaceutical Solids de Harry G. Brittain

Polymorphism in Pharmaceutical Solids: Drugs and the Pharmaceutical Sciences

Editat de Harry G. Brittain
en Limba Engleză Hardback – 27 iul 2009
Using clear and practical examples, Polymorphism of Pharmaceutical Solids, Second Edition presents a comprehensive examination of polymorphic behavior in pharmaceutical development that is ideal for pharmaceutical development scientists and graduate students in pharmaceutical science. This edition focuses on pharmaceutical aspects of polymorphism and solvatomorphism, while systematically explaining their thermodynamic and structural origins.
Topics include:
  • Computational methodologies
  • High-throughput screening methods
  • Pharmaceutical cocrystals
  • Thermally-induced and solution-mediated phase transformations
  • Amorphous solids
  • Crystallography preparation and characterization
  • The amorphous state
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Specificații

ISBN-13: 9781420073218
ISBN-10: 1420073214
Pagini: 652
Ilustrații: 200 b/w images
Dimensiuni: 152 x 229 x 41 mm
Greutate: 1.14 kg
Ediția:Revizuită
Editura: CRC Press
Colecția CRC Press
Seria Drugs and the Pharmaceutical Sciences

Locul publicării:Boca Raton, United States

Public țintă

Academic, Professional, and Professional Practice & Development

Cuprins

1. Thermodynamic and Theoretical Issues. 1.1. Theory and Origin of Polymorphism. 1.2. Application of the Phase Rule. 1.3. Computational Methodologies. 2. Preparative Methods for Polymorphs and Solvatomorphs. 2.1. Classical Methods of Preparation. 2.2. High-Throughput Screening Methods. 3. Structural Properties of Polymorphs and Solvatomorphs. 3.1. Polymorphic Systems. 3.2. Solvatomorphic Systems. 3.3. Pharmaceutical Cocrystals. 4. Characterization Methods for Polymorphs and Solvatomorphs. 4.1. Thermal and Crystallographic. 4.2. Vibrational Spectroscopy. 4.3. Solid-State NMR. 4.4. Solubility and Dissolution Rate. 5. Interconversion of Polymorphs and Solvatomorphs. 5.1. Thermally-Induced and Solution-Mediated Phase Transformations. 5.2. Effects of Secondary Processing. 5.3. Structural Aspects of Molecular Dissymmetry. 5.4. Amorphous Solids.

Descriere

Using clear and practical examples, this volume presents a comprehensive examination of polymorphic behavior in pharmaceutical development. The book is ideal for pharmaceutical development scientists and graduate students in pharmaceutical science. This second edition focuses on the pharmaceutical aspects of polymorphism and solvatomorphism, while systematically explaining their thermodynamic and structural origins. Topics in this edition include computational methodologies, high-throughput screening methods, pharmaceutical cocrystals, and thermally-induced and solution-mediated phase transformations. The book also examines amorphous solids, the amorphous state, and crystallography preparation and characterization.