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Pharmaceutical Powder Compaction Technology: Drugs and the Pharmaceutical Sciences

Editat de Metin Çelik
en Limba Engleză Hardback – 22 aug 2011
Compaction of powder constituents—both active ingredient and excipients—is examined to ensure consistent and reproducible disintegration and dispersion profiles. Revised to reflect modern pharmaceutical compacting techniques, this second edition of Pharmaceutical Powder Compaction Technology guides pharmaceutical engineers, formulation scientists, and product development and quality assurance personnel through the compaction formulation process and application.
This unique reference covers:
  • The physical structure of pharmaceutical compacts
  • Bonding phenomena that occur during powder compaction
  • Compression mechanisms of pharmaceutical particles
  • Theories and basic principles of powder compaction
New topics include:
  • Compaction data analysis techniques
  • The migration of powder constituents into commercial manufacture
  • Instrumentation for compaction
  • Compaction functionality testing, which is likely to become a USP requirement
  • Design space for compaction
  • Metrics required for scalability in tablet compression
  • Interactive compaction and preformulation database for commonly used excipients
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Specificații

ISBN-13: 9781420089172
ISBN-10: 142008917X
Pagini: 358
Ilustrații: 205 black & white illustrations, 41 black & white halftones, 165 black & white line drawings
Dimensiuni: 178 x 254 x 28 mm
Greutate: 0.86 kg
Ediția:Revizuită
Editura: CRC Press
Colecția CRC Press
Seria Drugs and the Pharmaceutical Sciences

Locul publicării:Boca Raton, United States

Public țintă

Academic, Professional, and Professional Practice & Development

Cuprins

Theory of Compaction: Intermolecular Bonding Forces: where materials and process come together. Compaction Data Analysis Techniques: Viscoelastic Models. Application of Percolation Theory and Fractal Geometry to Tablet Compaction. Post Compaction Data Analysis TechniquesIntrumentation and Equipment in Compaction: Tablet Press Instrumentation in the Research and Development Environment. Advanced Compaction Research Equipment: Compaction Simulators. Compactability Functionality Test. Role of Compaction in the Formulation and Process Development of Tabletting: Compaction Properties of Directly Compressible Materials. Lubrication Issues in Direct Compaction. Crystal Engineering and Particle Design for the Powder Compaction Process. Compaction of Combination Products. Quality by Design and Compression . Expert Systems and Their Use in Pharmaceutical Applications. Press-To-Press Scalability and Transitioning Factors.

Descriere

Revised to reflect modern pharmaceutical compacting techniques, this Second Edition explores compaction of powder constituents (both active ingredient and excipients) and guides pharmaceutical engineers, formulation scientists, product development and quality assurance personnel through the compaction formulation process to ensure consistent and reproducible disintegration and dispersion profiles. This unique reference describes the physical structure of pharmaceutical compacts, the bonding phenomena that occur during powder compaction, and the compression mechanisms of pharmaceutical particles.