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Pharmaceutical Extrusion Technology de Isaac Ghebre-Sellassie

Pharmaceutical Extrusion Technology: Drugs and the Pharmaceutical Sciences

Editat de Isaac Ghebre-Sellassie, Charles E. Martin, Feng Zhang, James DiNunzio
en Limba Engleză Paperback – 18 dec 2020
The first edition of Pharmaceutical Extrusion Technology, published in 2003, was deemed the seminal book on pharmaceutical extrusion. Now it is expanded and improved, just like the usage of extrusion has expanded, improved and evolved into an accepted manufacturing technology to continuously mix active pharmaceutical ingredients with excipients for a myriad of traditional and novel dosage forms.
Pharmaceutical Extrusion Technology, Second Edition reflects how this has spawned numerous research activities, in addition to hardware and process advancements. It offers new authors, expanded chapters and contains all the extrusion related technical information necessary for the development, manufacturing, and marketing of pharmaceutical dosage forms.


Key Features:




  • Reviews how extrusion has become an accepted technology to continuously mix active pharmaceutical ingredients with excipients


  • Focuses on equipment and process technology


  • Explains various extrusion system configurations as a manufacturing methodology for a variety of dosage forms


  • Presents new opportunities available only via extrusion and future trends


  • Includes contributions of experts from the process and equipment fields
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Specificații

ISBN-13: 9780367735081
ISBN-10: 0367735083
Pagini: 427
Dimensiuni: 156 x 234 mm
Greutate: 0.45 kg
Ediția:2
Editura: CRC Press
Colecția CRC Press
Seria Drugs and the Pharmaceutical Sciences

Locul publicării:Boca Raton, United States

Public țintă

Academic and Professional Practice & Development

Cuprins

Chapter 1: Twin Screw Extruders for Pharmaceutical Products from a Technical and Historical Perspective. Chapter 2: Extruder Design. Chapter 3: Control Strategy Considerations for Continuous Manufacturing using Hot Melt Extrusion. Chapter 4: Twin Screw Extrusion & Screw Design. Chapter 5: Die Design. Chapter 6: Feeding Technology and Material Handling for Pharmaceutical Extrusion. Chapter 7: Rheology, Torque and Oscillatory Rheometers. Chapter 8: Foam Extrusion. Chapter 9: Melt Pelletization and Size Reduction. Chapter 10: Extended Release Dosage Forms. Chapter 11: Shape Extrusion – Extruded Implantable Drug Delivery Devices: Materials, Applications and Processing. Chapter 12: Film, Sheet and Laminates. Chapter 13: Melt Extruded Amorphous Solid Dispersions. Chapter 14: Process Modeling and Simulation of Extrusion Operations. Chapter 15: Devolatilization via Twin Screw Extrusion: Theory, Tips, and Test Results. Chapter 16: Continuous Granulation Methodologies. Chapter 17: Installation, Commissioning & Qualification. Chapter 18: Extruder Control Systems.

Notă biografică

Isaac Ghebre-Sellassie is President, Pharmaceutical Technology Solutions, Morris Plains, New Jersey, and Executive Director and Chief Scientific Officer, MEGA Pharmaceuticals, Asmara, Eritrea. Dr. Ghebre-Sellassie is the author or coauthor of more than 50 professional publications, including Multiparticulate Oral Drug Delivery and Pharmaceutical Pelletization Technology (both titles, Marcel Dekker Inc.), and the holder of 17 patents. A member of the American Association of Pharmaceutical Scientists and the International Society for Pharmaceutical Engineering, he received his M.S. (1978) and Ph.D. (1981) degrees from Purdue University, West Lafayette, Indiana.


Charles Martin is President/General Manager of Leistritz Extrusion. He is responsible for the management of a company that provides manufacturing equipment and engineering services to the plastics, medical and pharmaceutical industries in the USA and around the world. Extensively published in trade publications, textbooks and journals, Charlie has delivered 100+ technical presentations at wide-ranging international events, and was the co-editor of the 1st edition of the textbook Pharmaceutical Extrusion Technology. He has been awarded 2 extrusion-related patents. Charlie earned his undergraduate degree from Gettysburg College, Gettysburg, Pennsylvania and MBA from Rutgers University, New Brunswick, New Jersey.


Feng Zhang is an assistant professor at the University of Texas at Austin. Dr. Zhang is the author and coauthor of more than 40 publications and more than 10 patents. A member of American Association of Pharmaceutical Scientist, he received his Ph.D. degree (1999) in Pharmaceutical Science from the University of Texas at Austin, Austin, Texas.


James DiNunzio is a Principal Scientist in the Formulation Sciences Group at Merck & Co., Inc. and currently leads the Hot-Melt Extrusion Subject Matter Expert team. He received his Ph.D. from the University of Texas at Austin in Pharmaceutics. He has published numerous research articles, book chapters, and is a co-inventor on multiple patents and patent applications. His current research interests include formulation design for melt extruded systems and the development of continuous manufacturing processes.

Descriere

Pharmaceutical Extrusion Technology, Second Edition brings together all extrusion related technical information necessary for the development, manufacturing, and marketing of pharmaceutical dosage forms.