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Autophagy Dysfunction in Alzheimer's Disease and Dementia de Tadanori Hamano

Autophagy Dysfunction in Alzheimer's Disease and Dementia

Editat de Tadanori Hamano, Tatsuro Mutoh
en Limba Engleză Paperback – 25 aug 2022
Autophagy Dysfunction in Alzheimer’s Disease and Dementia provides an overview for researchers and clinicians on the mechanisms involved in protein degradation in Alzheimer’s. The book discusses the implication of autophagy dysfunction in these diseases and how it causes degenerated proteins, including aggregated tau and aggregated amyloid protein. Other sections explores the possibilities of potential drug development through autophagy modulation, making this a great resource on the study of how autophagy dysfunction has been linked to the accumulation of misfolded proteins that cause death of neurons in Alzheimer’s and other neurodegenerative diseases.

  • Discusses the implication of autophagy dysfunction in neurodegenerative diseases
  • Highlights the mechanisms involved in protein degradation
  • Explores the possibilities of drug development through autophagy modulation
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Specificații

ISBN-13: 9780323899062
ISBN-10: 0323899064
Pagini: 356
Dimensiuni: 152 x 229 x 23 mm
Greutate: 0.57 kg
Editura: ELSEVIER SCIENCE

Cuprins

Section I. Degradation mechanisms of cells 1. Degradation mechanisms of cells
Section II. Lysosomes 2. Lysosomes-neuronal degeneration in lysosomal storage disorders
Section III. The autophagic pathways 3. The autophagy pathway and its key regulators
Section IV. Amyloid beta protein and autophagy 4. Basics of amyloid beta protein in Alzheimer’s disease 5. Molecular linkages among Aβ, tau, impaired mitophagy, and mitochondrial dysfunction in Alzheimer’s disease 6. Endocytosis in β-amyloid biology and Alzheimer’s disease
Section V. Autophagy and tau protein 7. Autophagy and tau protein 8. BAG3 promotes tau clearance by regulating autophagy and other vacuolar-dependent degradative processes  9. Tau propagation and autophagy
Section VI. Autophagy and pathology in Alzheimer’s disease 10. Granulovacuolar degeneration in neurodegeneration 11. Autophagy dysfunction in skeletal myopathies: Inclusion body myositis and Danon disease
Section VII. Autophagy and other disorders causing dementia 12. Autophagy in Lewy body diseases and multiple system atrophy     13. Autophagy and Huntington’s disease
Section VIII. Drug discovery in Alzheimer’s disease by modulating autophagy 14. Drug discovery in Alzheimer’s disease by regulating autophagy 15. Drug discovery in Alzheimer's disease using metal chelators: Warning toward their uses 16. Development of autophagy enhancers for Parkinson's disease therapy

Recenzii

" This book edited by Professors Hamano and Mutoh covers every important aspect of the cutting-edge neurosciences of autophagy in AD and other dementing disorders, including the degradation mechanism of misfolded proteins, A degradation mechanisms by autophagy and endocytosis, degradation mechanisms of tau by autophagy, impairment of mitophagy by A and tau accumulation, propagation of tau by autophagy dysfunction, pathological feature of autophagy, autophagy disturbances in inclusion body myositis and Danon disease, and autophagy defects in other diseases causing dementia, synucleinopathy and Huntington's disease. Perspectives on novel therapeutic strategies for AD, PD, or DLB by modulating autophagy also are widely discussed. I believe this comprehensive monograph on the role of autophagy in neurodegeneration will pave the way toward deeper understanding of the pathophysiology of neurodegenerative dementia and development of novel therapeutic methods to defeat AD and other dementias." --Takeshi Iwatsubo, MD, PhD, Professor and Chair, Department of Neuropathology, Graduate School of Medicine, The University of Tokyo